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<p>Pyroptosis is a recently identified form of programmed cell death that plays a crucial role in tumor development and immune regulation. It provides various novel perspectives on prognostic markers and possible therapeutic approaches. Unlike necrosis and apoptosis, pyroptosis, is characterized by the activation of pore-forming protein called gasdermin D (GSDMD), which is cleaved by caspase enzymes to form oligomers that disrupt the cell membrane, leading to rapid cell lysis. The interaction between pyroptosis and immunotherapy presents promising opportunities to enhance cancer treatments and improve patient outcomes. However, despite extensive research, the underlying mechanisms of pyroptosis are not yet fully understood. Recent advancements have focused on noninvasive and real-time imaging techniques to elucidate pyroptosis dynamics at the molecular level. This review comprehensively discusses innovative monitoring strategies, including molecular probes, nanotechnology-based tools, and computational approaches, which provide valuable insights into pyroptosis regulation. By leveraging these advanced methodologies, researchers can refine therapeutic strategies, paving the way for more effective and personalized treatments for cancer and inflammatory diseases.</p>

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Innovative Nanotechnology and Molecular Probes for Real-time Monitoring and Therapeutic Modulation of Pyroptosis in Cancer and Inflammatory Diseases

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • Wajahat Ali,
  • Zainab Saba,
  • Muhammad Saqib,
  • Shabana Batool,
  • Awais,
  • Fatima Rahman,
  • Ali Asgher Shuja,
  • Junaid Abid,
  • Seema Batool,
  • Kulsoom,
  • Mukhayya Ruzieva,
  • Murodjon Yaxshimuratov,
  • Ravshan Sultanov,
  • Yuldoshev Jushkinbek Erkaboy ugli

摘要

Pyroptosis is a recently identified form of programmed cell death that plays a crucial role in tumor development and immune regulation. It provides various novel perspectives on prognostic markers and possible therapeutic approaches. Unlike necrosis and apoptosis, pyroptosis, is characterized by the activation of pore-forming protein called gasdermin D (GSDMD), which is cleaved by caspase enzymes to form oligomers that disrupt the cell membrane, leading to rapid cell lysis. The interaction between pyroptosis and immunotherapy presents promising opportunities to enhance cancer treatments and improve patient outcomes. However, despite extensive research, the underlying mechanisms of pyroptosis are not yet fully understood. Recent advancements have focused on noninvasive and real-time imaging techniques to elucidate pyroptosis dynamics at the molecular level. This review comprehensively discusses innovative monitoring strategies, including molecular probes, nanotechnology-based tools, and computational approaches, which provide valuable insights into pyroptosis regulation. By leveraging these advanced methodologies, researchers can refine therapeutic strategies, paving the way for more effective and personalized treatments for cancer and inflammatory diseases.