<p>Hyperlipidemia, marked by elevated triglycerides and cholesterol, is linked to degenerative diseases often worsened by free radicals. <i>Balliospermum montanum</i> roots, rich in flavonoids and phenolic compounds, exhibit antioxidant properties, but their antihyperlipidemic potential remains underexplored. This study aimed to extract, fractionate, and analyze the phytochemical composition of <i>B. montanum</i> roots, evaluating their docking, antioxidant, and antihyperlipidemic activities. Extraction was performed using 96% methanol, followed by liquid-liquid fractionation with n-hexane, ethyl acetate, chloroform, and methanol. Phytochemical screening and antioxidant assays were conducted on the methanol extract, with in-silico docking assessing binding interactions of key compounds with target enzymes. Docking revealed Baliospermin and montanin had the highest binding affinity for HMG-CoA reductase and lipase, respectively. Methanol extraction yielded 13.87%, with the methanol fraction producing the highest dried extract (39.37%). Phytochemical analysis identified flavonoids, phenolic compounds, and other bioactive constituents. The ethyl acetate fraction showed the lowest IC₅₀ values, indicating the strongest antioxidant activity, and exhibited the highest antihyperlipidemic potential. This study highlights the phytochemical composition of <i>B. montanum</i> roots and underscores the significant docking, antioxidant, and antihyperlipidemic properties of its fractions, supporting its potential therapeutic use.</p>