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<p>This study aimed to evaluate how different levels of boric acid (BA) supplementation affect performance, serum biochemistry, endoplasmic reticulum (ER) stress, and intestinal structure in late-laying hens subjected to feed restriction. We randomly assigned 180 laying hens, 70 weeks old, into six groups: a non-feed-restricted control group (CON1), non-feed-restricted groups supplemented with 60&#xa0;mg/kg feed (B60-1) and 90&#xa0;mg/kg feed (B90-1) of BA, a feed-restricted control group (CON2), and feed-restricted groups supplemented with 60&#xa0;mg/kg feed (B60-2) and 90&#xa0;mg/kg feed (B90-2) of BA. The experiment lasted 56 days. Feed restriction significantly reduced egg production and body weight (<i>p</i> &lt; 0.05). However, feed efficiency improved in the feed-restricted control group (CON2) (<i>p</i> &lt; 0.05). In serum biochemical analyses, Alanine transaminase (ALT) levels were lower in the B60-1 group, while triglyceride and total cholesterol levels were lowest in the B90-2 group. Uric acid levels were highest in the CON2 group (<i>p</i> &lt; 0.05), and total protein levels decreased in the B90-2 group (<i>p</i> &lt; 0.05). Nrf-2, GCLC, and GCLM levels were higher in the control groups (CON1 and CON2) compared with BA-supplemented groups (<i>p</i> &lt; 0.01). ATF-4, ATF-6, IRE-1, and CHOP levels significantly increased in the feed-restricted control group (CON2) and decreased with BA supplementation (<i>p</i> ≤ 0.005). While we did not observe significant differences in duodenal structure (<i>p</i> &gt; 0.05), feed restriction caused reductions in villus height and epithelial height in the jejunum and ileum. These reductions were partially improved in the B60-2 and B90-2 groups (<i>p</i> &lt; 0.05). In conclusion, BA supplementation during feed restriction may help maintain intestinal integrity, adjust cellular stress responses, and support performance-related metabolic changes in late-laying hens.</p>

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Effects of Dietary Boron Supplementation on Performance, Egg Quality, and Physiological Responses in Late-Laying Hens Subjected to Feed Restriction

  • 期刊论文

  • 发表日期：

    2026年7月6日

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  • Soner Uysal,
  • Şeyma Taş,
  • Elif Erbaş,
  • Ayşe Uysal

摘要

This study aimed to evaluate how different levels of boric acid (BA) supplementation affect performance, serum biochemistry, endoplasmic reticulum (ER) stress, and intestinal structure in late-laying hens subjected to feed restriction. We randomly assigned 180 laying hens, 70 weeks old, into six groups: a non-feed-restricted control group (CON1), non-feed-restricted groups supplemented with 60 mg/kg feed (B60-1) and 90 mg/kg feed (B90-1) of BA, a feed-restricted control group (CON2), and feed-restricted groups supplemented with 60 mg/kg feed (B60-2) and 90 mg/kg feed (B90-2) of BA. The experiment lasted 56 days. Feed restriction significantly reduced egg production and body weight (p < 0.05). However, feed efficiency improved in the feed-restricted control group (CON2) (p < 0.05). In serum biochemical analyses, Alanine transaminase (ALT) levels were lower in the B60-1 group, while triglyceride and total cholesterol levels were lowest in the B90-2 group. Uric acid levels were highest in the CON2 group (p < 0.05), and total protein levels decreased in the B90-2 group (p < 0.05). Nrf-2, GCLC, and GCLM levels were higher in the control groups (CON1 and CON2) compared with BA-supplemented groups (p < 0.01). ATF-4, ATF-6, IRE-1, and CHOP levels significantly increased in the feed-restricted control group (CON2) and decreased with BA supplementation (p ≤ 0.005). While we did not observe significant differences in duodenal structure (p > 0.05), feed restriction caused reductions in villus height and epithelial height in the jejunum and ileum. These reductions were partially improved in the B60-2 and B90-2 groups (p < 0.05). In conclusion, BA supplementation during feed restriction may help maintain intestinal integrity, adjust cellular stress responses, and support performance-related metabolic changes in late-laying hens.