Scholarlink

<p>The effect of orally administered gadolinium-europium orthovanadate nanoparticles (GdVO<sub>4</sub>:Eu<sup>3+</sup> NPs) on the course and progression of diabetes and vascular malfunction in rats with type 2 diabetes (T2DM) was studied. Long-term GdVO<sub>4</sub>:Eu<sup>3+</sup> NPs administration with drinking water for 28 days at a dose of 0.3–0.4&#xa0;mg/kg normalized blood glucose content and slightly increased the level of the insulin precursor, C-peptide. The glucose tolerance test demonstrated a decrease in the area under the glucose curve, a rise in fractional glucose clearance, and a return to normal glucose levels. The used T2DM model had no visible effect on endothelium-dependent vasodilator responses in the rat thoracic aorta. Administration of GdVO<sub>4</sub>:Eu<sup>3+</sup> NPs also did not alter these responses. The results of the present study suggested that GdVO<sub>4</sub>:Eu<sup>3+</sup> NPs have a positive effect on glucose homeostasis in experimental type 2 diabetes in rats, while the mechanisms underlying this effect require further investigation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gadolinium Orthovanadate Nanoparticles Normalizes Glycemia, Insulin Resistance, and Glucose Tolerance in Rats with Experimental Type 2 Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2026年5月26日

查看全文
  • Vadym Sydorenko,
  • Nina Karpenko,
  • Irina Ivanova,
  • Olexandr Parshikov,
  • Anatoly Soloviev,
  • Nataliya Kavok,
  • Vladimir Klochkov,
  • Vladimir Semynozhenko,
  • Svitlana Yefimova

摘要

The effect of orally administered gadolinium-europium orthovanadate nanoparticles (GdVO4:Eu3+ NPs) on the course and progression of diabetes and vascular malfunction in rats with type 2 diabetes (T2DM) was studied. Long-term GdVO4:Eu3+ NPs administration with drinking water for 28 days at a dose of 0.3–0.4 mg/kg normalized blood glucose content and slightly increased the level of the insulin precursor, C-peptide. The glucose tolerance test demonstrated a decrease in the area under the glucose curve, a rise in fractional glucose clearance, and a return to normal glucose levels. The used T2DM model had no visible effect on endothelium-dependent vasodilator responses in the rat thoracic aorta. Administration of GdVO4:Eu3+ NPs also did not alter these responses. The results of the present study suggested that GdVO4:Eu3+ NPs have a positive effect on glucose homeostasis in experimental type 2 diabetes in rats, while the mechanisms underlying this effect require further investigation.