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<p>This study aimed to evaluate the effects of boron on the lipid metabolism, estradiol concentration, uterine morphology and ERα expression in ovariectomized rats. Seventy 3-month-old female SD rats were selected and randomly divided into a sham-operated group and an ovariectomized group. After one week of surgical recovery, sham-operated rats were divided into Sham (distilled water) and Sham+B40 (40&#xa0;mg/L boron) groups. Ovariectomized rats were allocated to OVX (control), OVX + Est (estrogen), OVX+B20 (20&#xa0;mg/L boron), OVX+B40 (40&#xa0;mg/L boron) and OVX+B80 (80&#xa0;mg/L boron) groups. During the 22-week experiment period, body weight was recorded; serum lipid profiles (TC, TG, LDL-C and HDL-C) and estradiol (E<sub>2</sub>) levels were detected; uterine morphology was observed; uterine ERα expression was analyzed via qRT-PCR and immunohistochemistry. The results showed that the body weight and lipid metabolism levels in the three boron-supplemented groups were generally increased compared to those of the OVX group and the Sham group. The concentration of E<sub>2</sub> was increased to a different degree. Uterine area and endometrial thickness increased with 20&#xa0;mg/L and 40&#xa0;mg/L boron but decreased at 80&#xa0;mg/L. Although the expression levels of uterine ERα in the three boron-supplemented groups were different degree increased, the 20&#xa0;mg/L group was showed the best result. Therefore, that boron demonstrates estrogen-modulatory effects, which can effectively improve the estrogen deficiency symptoms in ovariectomized rats, regulate lipid metabolism disorders, increase E<sub>2</sub> concentration, alleviate degree of the uterine atrophy and promote the expression of ERα, especially the low-concentration (20&#xa0;mg/L) boron has a better effect.</p>

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Effects of Boron on the Lipid Metabolism, Estradiol Concentration, Uterine Morphology and ERα Expression in Ovariectomized Rats

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • Ziyan Li,
  • Qinglan Liu,
  • Lin Wang,
  • Chun Wang,
  • Long Wang,
  • Shenghe Li,
  • Qianqian Hu

摘要

This study aimed to evaluate the effects of boron on the lipid metabolism, estradiol concentration, uterine morphology and ERα expression in ovariectomized rats. Seventy 3-month-old female SD rats were selected and randomly divided into a sham-operated group and an ovariectomized group. After one week of surgical recovery, sham-operated rats were divided into Sham (distilled water) and Sham+B40 (40 mg/L boron) groups. Ovariectomized rats were allocated to OVX (control), OVX + Est (estrogen), OVX+B20 (20 mg/L boron), OVX+B40 (40 mg/L boron) and OVX+B80 (80 mg/L boron) groups. During the 22-week experiment period, body weight was recorded; serum lipid profiles (TC, TG, LDL-C and HDL-C) and estradiol (E2) levels were detected; uterine morphology was observed; uterine ERα expression was analyzed via qRT-PCR and immunohistochemistry. The results showed that the body weight and lipid metabolism levels in the three boron-supplemented groups were generally increased compared to those of the OVX group and the Sham group. The concentration of E2 was increased to a different degree. Uterine area and endometrial thickness increased with 20 mg/L and 40 mg/L boron but decreased at 80 mg/L. Although the expression levels of uterine ERα in the three boron-supplemented groups were different degree increased, the 20 mg/L group was showed the best result. Therefore, that boron demonstrates estrogen-modulatory effects, which can effectively improve the estrogen deficiency symptoms in ovariectomized rats, regulate lipid metabolism disorders, increase E2 concentration, alleviate degree of the uterine atrophy and promote the expression of ERα, especially the low-concentration (20 mg/L) boron has a better effect.