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<p>Titanium carbonate nanoparticles (TiCO<sub>3</sub> NPs) were synthesized and extensively characterized using advanced spectroscopic and microscopic techniques to confirm their crystalline structure, morphology, and stability. Biocompatibility assessments revealed minimal cytotoxicity, supporting their potential for biomedical applications. The therapeutic efficacy of TiCO<sub>3</sub> NPs was investigated in a diabetic mouse model, where oral administration significantly improved glycemic control, reduced fasting blood glucose levels, and enhanced insulin sensitivity compared to untreated controls. In parallel, the antibacterial potential of TiCO<sub>3</sub> NPs was evaluated against clinically relevant pathogens, including <i>Enterobacter sp.</i>, and <i>Staphylococcus aureus</i>. These results confirm the broad-spectrum antibacterial potential of TiCO<sub>3</sub>, highlighting their capacity to disrupt both Gram-positive and Gram-negative bacteria. Collectively, these findings establish TiCO<sub>3</sub> NPs as a multifunctional nanomaterial with excellent biocompatibility, effective glycemic regulation in diabetic models, and broad-spectrum antibacterial activity, positioning them as promising candidates for therapeutic and biomedical applications.</p>

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Synthesis and Biomedical Potential of TiCO3 Nanoparticles in Diabetes and Infection

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Noman Nazeer,
  • Feruza Khudaykulova,
  • Zarifa Mamadiyeva,
  • Subbulakshmi Ganesan,
  • Samir Sahoo,
  • Amrita Pal,
  • Vimal Arora,
  • Shekhar Singh

摘要

Titanium carbonate nanoparticles (TiCO3 NPs) were synthesized and extensively characterized using advanced spectroscopic and microscopic techniques to confirm their crystalline structure, morphology, and stability. Biocompatibility assessments revealed minimal cytotoxicity, supporting their potential for biomedical applications. The therapeutic efficacy of TiCO3 NPs was investigated in a diabetic mouse model, where oral administration significantly improved glycemic control, reduced fasting blood glucose levels, and enhanced insulin sensitivity compared to untreated controls. In parallel, the antibacterial potential of TiCO3 NPs was evaluated against clinically relevant pathogens, including Enterobacter sp., and Staphylococcus aureus. These results confirm the broad-spectrum antibacterial potential of TiCO3, highlighting their capacity to disrupt both Gram-positive and Gram-negative bacteria. Collectively, these findings establish TiCO3 NPs as a multifunctional nanomaterial with excellent biocompatibility, effective glycemic regulation in diabetic models, and broad-spectrum antibacterial activity, positioning them as promising candidates for therapeutic and biomedical applications.