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<p>Schiff base complexes possess many biological activities, including antibacterial and antitumor activities. However, the anti-cervical cancer activity of Ag (Ⅰ) Schiff base complex or its corresponding molecular mechanism remains limited. Here, we showed that Ag (Ⅰ) Schiff base complex Ag34 significantly inhibited the proliferation of cervical cancer cells. Subsequent studies on the anti-cervical cancer mechanism of Ag34 revealed that Ag34 inactivated TrxR, which led to ROS accumulation. Ag34-induced ROS accumulation promoted ASK1/MAPK signaling activation and autophagy, thereby triggering apoptosis of cervical cancer cells. Taken together, Ag34 has the potential to be used in the treatment of cervical cancer.</p>

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Inhibitory Effect of TrxR Inhibitor Ag (Ⅰ) Schiff Base Complex Against Cervical Cancer Via ROS-mediated ASK1/MAPK Signaling and Autophagy

  • 期刊论文

  • 发表日期：

    2025年11月9日

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  • Jian-Jun Liu,
  • Jia-Hua Zou,
  • Bin Dong,
  • Xue-Ping Lu,
  • Li-Feng Chen,
  • San-Mei Ma,
  • Zhong Liu

摘要

Schiff base complexes possess many biological activities, including antibacterial and antitumor activities. However, the anti-cervical cancer activity of Ag (Ⅰ) Schiff base complex or its corresponding molecular mechanism remains limited. Here, we showed that Ag (Ⅰ) Schiff base complex Ag34 significantly inhibited the proliferation of cervical cancer cells. Subsequent studies on the anti-cervical cancer mechanism of Ag34 revealed that Ag34 inactivated TrxR, which led to ROS accumulation. Ag34-induced ROS accumulation promoted ASK1/MAPK signaling activation and autophagy, thereby triggering apoptosis of cervical cancer cells. Taken together, Ag34 has the potential to be used in the treatment of cervical cancer.