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<p>The recommended nutrient intakes (RNI) for iodine in preschool children in China are outdated. The study aimed to establish optimal iodine intake for Chinese preschool children aged 3–6&#xa0;years using a modified iodine balance methodology. During the 3-day iodine balance study, 75 healthy preschool children aged 3–6&#xa0;years were randomly divided into three groups. Dietary interventions were applied to bal-ance the proportion of children with positive and negative iodine balance across groups. All food items consumed and excreta (urine, feces) were systematically col-lected to analyze the relationships among daily iodine intake, excretion, and retention. A total of 42 children (56.0%) were in negative iodine balance, while 33 children (44.0%) were in positive iodine balance. The zero iodine balance value (defined as the iodine intake level at which intake equals excretion) among the three groups increased with higher iodine intake. A significant positive association was observed between iodine intake and iodine excretion (β: 0.45; 95% CI: 0.30, 0.60; <i>P</i> &lt; 0.001), with an obligatory iodine excretion of 36&#xa0;μg/d. Additionally, iodine intake was significantly associ-ated with increased iodine retention (β: 0.55; 95% CI: 0.40, 0.70; <i>P</i> &lt; 0.001). The zero io-dine balance value for preschool children aged 3–6&#xa0;years was determined to be 65.6&#xa0;μg/d. Our study estimated the estimated average requirement (EAR) for iodine in preschool children aged 3–6&#xa0;years in China to be 65.6&#xa0;μg/d, and the calculated RNI is 90&#xa0;μg/d. Our study provides critical data support for establishing China’s dietary reference intakes for iodine.</p>

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A Modified Iodine Balance Study to Explore the Recommended Nutrient Intake of Iodine in Chinese Preschool Children Aged 3 to 6 Years

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Rui Yang,
  • Qi Jin,
  • Dong An,
  • Dongping Lv,
  • Yidan Wei,
  • Elizabeth N. Pearce,
  • Junhong Yang,
  • Dongmei Meng,
  • Jiayi Zhang,
  • Weiwei Gao,
  • Wen Chen

摘要

The recommended nutrient intakes (RNI) for iodine in preschool children in China are outdated. The study aimed to establish optimal iodine intake for Chinese preschool children aged 3–6 years using a modified iodine balance methodology. During the 3-day iodine balance study, 75 healthy preschool children aged 3–6 years were randomly divided into three groups. Dietary interventions were applied to bal-ance the proportion of children with positive and negative iodine balance across groups. All food items consumed and excreta (urine, feces) were systematically col-lected to analyze the relationships among daily iodine intake, excretion, and retention. A total of 42 children (56.0%) were in negative iodine balance, while 33 children (44.0%) were in positive iodine balance. The zero iodine balance value (defined as the iodine intake level at which intake equals excretion) among the three groups increased with higher iodine intake. A significant positive association was observed between iodine intake and iodine excretion (β: 0.45; 95% CI: 0.30, 0.60; P < 0.001), with an obligatory iodine excretion of 36 μg/d. Additionally, iodine intake was significantly associ-ated with increased iodine retention (β: 0.55; 95% CI: 0.40, 0.70; P < 0.001). The zero io-dine balance value for preschool children aged 3–6 years was determined to be 65.6 μg/d. Our study estimated the estimated average requirement (EAR) for iodine in preschool children aged 3–6 years in China to be 65.6 μg/d, and the calculated RNI is 90 μg/d. Our study provides critical data support for establishing China’s dietary reference intakes for iodine.