Scholarlink

<p>Preeclampsia is a hypertensive disorder of pregnancy associated with significant maternal and perinatal morbidity. Emerging evidence suggests that deficiencies in micronutrients such as magnesium and zinc may contribute to its pathogenesis. This study aimed to compare serum magnesium and zinc levels between pregnant women with preeclampsia and healthy controls and to evaluate their association with preeclampsia risk. In this case–control study conducted at Fatemieh Hospital, Hamadan, Iran (2023–2024), 89 pregnant women diagnosed with preeclampsia and 81 matched healthy pregnant controls were enrolled. Serum magnesium and zinc concentrations were measured using commercial kits and biochemical analyzers. Comprehensive demographic, obstetric, and laboratory data were gathered, and statistical analyses were performed using independent t-tests and multivariate logistic regression. Serum magnesium (1.08 ± 0.23 mg/dL vs. 1.21 ± 0.32 mg/dL, <i>p</i> &lt; 0.001) and zinc levels (68.5 ± 7.8 µg/dL vs. 91.5 ± 10.9 µg/dL, <i>p</i> &lt; 0.001) were significantly lower in the preeclampsia group compared to controls. Multivariate analysis indicated that each unit increase in serum magnesium and zinc was associated with decreased odds of preeclampsia (OR = 0.024; 95% CI: 0.002–0.277 and OR = 0.720; 95% CI: 0.625–0.829, respectively). Blood group and proteinuria also independently predicted preeclampsia risk. No significant correlations were found between micronutrient levels and demographic or other laboratory variables (<i>p</i> &gt; 0.05). The findings suggest that lower maternal serum magnesium and zinc concentrations are significantly associated with increased risk of preeclampsia. Routine monitoring and appropriate supplementation of these micronutrients during pregnancy may help identify at-risk women and reduce adverse outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Serum Magnesium and Zinc Levels in Pregnant Women with Preeclampsia Compared to Healthy Controls: Case–Control Study

  • 期刊论文

  • 发表日期：

    2025年10月17日

查看全文
  • Aida Alizamir,
  • Negin Fallah,
  • Maryam Ahmadi,
  • Elahe Talebi Ghane

摘要

Preeclampsia is a hypertensive disorder of pregnancy associated with significant maternal and perinatal morbidity. Emerging evidence suggests that deficiencies in micronutrients such as magnesium and zinc may contribute to its pathogenesis. This study aimed to compare serum magnesium and zinc levels between pregnant women with preeclampsia and healthy controls and to evaluate their association with preeclampsia risk. In this case–control study conducted at Fatemieh Hospital, Hamadan, Iran (2023–2024), 89 pregnant women diagnosed with preeclampsia and 81 matched healthy pregnant controls were enrolled. Serum magnesium and zinc concentrations were measured using commercial kits and biochemical analyzers. Comprehensive demographic, obstetric, and laboratory data were gathered, and statistical analyses were performed using independent t-tests and multivariate logistic regression. Serum magnesium (1.08 ± 0.23 mg/dL vs. 1.21 ± 0.32 mg/dL, p < 0.001) and zinc levels (68.5 ± 7.8 µg/dL vs. 91.5 ± 10.9 µg/dL, p < 0.001) were significantly lower in the preeclampsia group compared to controls. Multivariate analysis indicated that each unit increase in serum magnesium and zinc was associated with decreased odds of preeclampsia (OR = 0.024; 95% CI: 0.002–0.277 and OR = 0.720; 95% CI: 0.625–0.829, respectively). Blood group and proteinuria also independently predicted preeclampsia risk. No significant correlations were found between micronutrient levels and demographic or other laboratory variables (p > 0.05). The findings suggest that lower maternal serum magnesium and zinc concentrations are significantly associated with increased risk of preeclampsia. Routine monitoring and appropriate supplementation of these micronutrients during pregnancy may help identify at-risk women and reduce adverse outcomes.