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<p>The etiology of chronic kidney disease (CKD) is complex, with environmental copper exposure emerging as a non-traditional risk factor whose nephrotoxic mechanisms and impacts require in-depth investigation. This study conducted a retrospective analysis of 36 patients with abnormally elevated urinary copper levels, evaluating their clinical manifestations, biochemical indicators, and responses following copper chelation therapy, along with a literature review to explore the relationship between copper levels and renal injury. The results demonstrated a significant correlation between urinary copper content and the severity of renal dysfunction (<i>P</i> &lt; 0.001). After treatment, improvements were observed in renal function (BUA <i>P</i> = 0.046), liver function (ALT <i>P</i> = 0.013), and anemia indicators (HGB <i>P</i> = 0.034). These findings indicate that abnormal urinary copper is a risk factor for kidney injury.</p>

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Copper-Induced Nephropathy: Clinical Characterization of 36 Cases and Comprehensive Literature Review

  • 期刊论文

  • 发表日期：

    2025年11月13日

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  • Yi-Ling Li,
  • Jing Chen,
  • Jin-Rong Zhang,
  • Ting-Ting Zhou,
  • Jian-chao Peng,
  • Zhi-Xin Huang,
  • Kang Nong,
  • Michael Aschner,
  • Yue-Ming Jiang

摘要

The etiology of chronic kidney disease (CKD) is complex, with environmental copper exposure emerging as a non-traditional risk factor whose nephrotoxic mechanisms and impacts require in-depth investigation. This study conducted a retrospective analysis of 36 patients with abnormally elevated urinary copper levels, evaluating their clinical manifestations, biochemical indicators, and responses following copper chelation therapy, along with a literature review to explore the relationship between copper levels and renal injury. The results demonstrated a significant correlation between urinary copper content and the severity of renal dysfunction (P < 0.001). After treatment, improvements were observed in renal function (BUA P = 0.046), liver function (ALT P = 0.013), and anemia indicators (HGB P = 0.034). These findings indicate that abnormal urinary copper is a risk factor for kidney injury.