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Background <p>Copper is an essential trace element involved in numerous enzymatic functions and physiological processes. Chronic kidney disease (CKD) and hemodialysis (HD) may influence copper homeostasis, yet conflicting findings exist regarding copper levels in these patients and copper levels aren’t routinely checked. This systematic review and meta-analysis evaluates serum copper concentrations in CKD and HD patients compared to healthy controls (HC), and assesses changes pre- and post-HD.</p> Methods <p>A systematic search of PubMed, Scopus, Cochrane Library, EMBASE, and Web of Science was conducted up to February 2025. Observational studies reporting serum copper levels in CKD and HD patients were included. Data analysis were conducted using RevMan software. The data were pooled as standardized&#xa0;mean difference (SMD) and using a random-effects model.</p> Results <p>A total of 42 studies with 13,592 participants were included. No significant difference in copper levels was observed between CKD patients and HC (SMD: -0.18, 95% CI: -1.17, 0.80; P = 0.71). However, HD patients had significantly lower copper levels compared to HC (SMD: -0.48, 95% CI: -0.89, -0.07; P = 0.02). Additionally, HD significantly reduced serum copper levels post-treatment compared to pre-HD (SMD: -0.41, 95% CI: -0.62, -0.21; P &lt; 0.0001).</p> Conclusion <p>Our findings suggest that CKD does not significantly impact serum copper levels, whereas HD leads to a significant decrease in copper concentrations. The mechanisms underlying this reduction require further elucidation, and future studies should explore the potential clinical consequences of low copper levels in HD patients.</p>

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Serum Copper Levels in Chronic Kidney Disease and Hemodialysis Patients: Insights from a Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年4月30日

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  • Abdullah Yousef Aldalati,
  • Ayham Mohammad Hussein,
  • Elsayed Balbaa,
  • Bassel Alrabadi,
  • Moath Albliwi,
  • Mohammad Abuassi,
  • Badi Rawashdeh

摘要

Background

Copper is an essential trace element involved in numerous enzymatic functions and physiological processes. Chronic kidney disease (CKD) and hemodialysis (HD) may influence copper homeostasis, yet conflicting findings exist regarding copper levels in these patients and copper levels aren’t routinely checked. This systematic review and meta-analysis evaluates serum copper concentrations in CKD and HD patients compared to healthy controls (HC), and assesses changes pre- and post-HD.

Methods

A systematic search of PubMed, Scopus, Cochrane Library, EMBASE, and Web of Science was conducted up to February 2025. Observational studies reporting serum copper levels in CKD and HD patients were included. Data analysis were conducted using RevMan software. The data were pooled as standardized mean difference (SMD) and using a random-effects model.

Results

A total of 42 studies with 13,592 participants were included. No significant difference in copper levels was observed between CKD patients and HC (SMD: -0.18, 95% CI: -1.17, 0.80; P = 0.71). However, HD patients had significantly lower copper levels compared to HC (SMD: -0.48, 95% CI: -0.89, -0.07; P = 0.02). Additionally, HD significantly reduced serum copper levels post-treatment compared to pre-HD (SMD: -0.41, 95% CI: -0.62, -0.21; P < 0.0001).

Conclusion

Our findings suggest that CKD does not significantly impact serum copper levels, whereas HD leads to a significant decrease in copper concentrations. The mechanisms underlying this reduction require further elucidation, and future studies should explore the potential clinical consequences of low copper levels in HD patients.