Scholarlink

<p>Selenium plays a role in the context of heart failure (HF), but still, there are gaps regarding the factors associated with selenium status, as well as its association with the prognosis of HF. We aimed to investigate predictors of plasma selenium and its association with hospitalization and all-cause mortality. This prospective cohort study included 80 outpatients with HF. Non-elective hospitalization and all-cause mortality were assessed during 36&#xa0;months of follow-up. The associations between plasma selenium, dietary selenium intake, and sociodemographic, clinical, and biochemical parameters were evaluated by a multiple linear regression model. The risk of these clinical outcomes was assessed with multivariate Cox regression and cubic splines analysis. Albumin (<i>β</i> = 0.113, <i>p</i> &lt; 0.001; <i>R</i><sup>2</sup> = 0.291) and triacylglycerol levels (<i>β</i> = 0.0002, <i>p</i> &lt; 0.021, <i>R</i><sup>2</sup> = 0.376) were predictors of plasma selenium&#xa0;levels. No significant associations were found between dietary selenium intake&#xa0;and plasma selenium tertiles with&#xa0;hospitalization and all-cause mortality (all <i>p</i> &gt; 0.05). The cubic splines analysis revealed that both low and high selenium concentrations influence these outcomes. The predictors of plasma selenium were related to the clinical conditions of HF. Selenium in plasma should be interpreted cautiously, considering that low and high levels may be associated with risks of adverse outcomes in HF.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictors of Plasma Selenium Levels and Association with Prognosis in Outpatients with Heart Failure: a 36-Month Prospective Cohort Study

  • 期刊论文

  • 发表日期：

    2025年4月4日

查看全文
  • Isabelli Luara Costa da Silva,
  • Bruna Zavarize Reis,
  • Fernanda Lambert de Andrade Freire,
  • Niethia Regina Dantas de Lira,
  • Rosiane Viana Zuza Diniz,
  • Lucia Fátima Campos Pedrosa,
  • Severina Carla Vieira Cunha Lima,
  • Leonardo Santos Hoff,
  • Folorunsho Bright Omage,
  • Fernando Barbosa Jr.,
  • Karine Cavalcanti Mauricio Sena-Evangelista

摘要

Selenium plays a role in the context of heart failure (HF), but still, there are gaps regarding the factors associated with selenium status, as well as its association with the prognosis of HF. We aimed to investigate predictors of plasma selenium and its association with hospitalization and all-cause mortality. This prospective cohort study included 80 outpatients with HF. Non-elective hospitalization and all-cause mortality were assessed during 36 months of follow-up. The associations between plasma selenium, dietary selenium intake, and sociodemographic, clinical, and biochemical parameters were evaluated by a multiple linear regression model. The risk of these clinical outcomes was assessed with multivariate Cox regression and cubic splines analysis. Albumin (β = 0.113, p < 0.001; R2 = 0.291) and triacylglycerol levels (β = 0.0002, p < 0.021, R2 = 0.376) were predictors of plasma selenium levels. No significant associations were found between dietary selenium intake and plasma selenium tertiles with hospitalization and all-cause mortality (all p > 0.05). The cubic splines analysis revealed that both low and high selenium concentrations influence these outcomes. The predictors of plasma selenium were related to the clinical conditions of HF. Selenium in plasma should be interpreted cautiously, considering that low and high levels may be associated with risks of adverse outcomes in HF.