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<p>Silica nanoparticles (SiO₂ NPs) are versatile nanomaterials with tunable physicochemical properties and excellent biocompatibility, making them suitable for biomedical applications. In this study, a green synthesis approach was employed using <i>Origanum majorana</i> leaf extract as a natural reducing and stabilizing agent to fabricate biofunctionalized SiO₂ nanoparticles. The novelty of this work lies in utilizing a phytochemically rich yet underexplored plant source for synthesizing silica nanoparticles and systematically evaluating their multifunctional biological properties. The synthesized nanoparticles were characterized using UV–Vis spectroscopy, FTIR, XRD, FESEM, EDX, and DLS analyses, confirming the formation of amorphous, high-purity SiO₂ nanoparticles with Si–O–Si and Si–OH functional groups. FESEM analysis revealed particle sizes of 50–200&#xa0;nm, while DLS indicated a hydrodynamic diameter of 298.3&#xa0;nm (PDI = 0.496). The nanoparticles exhibited significant antioxidant activity (96.7% DPPH scavenging at 10&#xa0;µg/mL), concentration-dependent antimicrobial effects, notable anti-inflammatory activity (IC₅₀ = 165 µL), and moderate cytotoxicity against L929 fibroblast cells (IC₅₀ = 112.06&#xa0;µg/mL). This study presents an eco-friendly strategy for producing biofunctionalized silica nanoparticles with promising applications in nanomedicine and antimicrobial therapy.</p>

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Green Synthesis and Characterization of SiO2 Nanoparticles Using Origanum majorana Leaf Extract and Evaluation of its Biological Potential

  • 期刊论文

  • 发表日期：

    2026年7月9日

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  • Hari Priya Jaisankar,
  • Prabhakaran Divya,
  • Jaimohan Seetharani Murugaiyan,
  • Madheslu Manikandan,
  • Sadhasivam Narendhran

摘要

Silica nanoparticles (SiO₂ NPs) are versatile nanomaterials with tunable physicochemical properties and excellent biocompatibility, making them suitable for biomedical applications. In this study, a green synthesis approach was employed using Origanum majorana leaf extract as a natural reducing and stabilizing agent to fabricate biofunctionalized SiO₂ nanoparticles. The novelty of this work lies in utilizing a phytochemically rich yet underexplored plant source for synthesizing silica nanoparticles and systematically evaluating their multifunctional biological properties. The synthesized nanoparticles were characterized using UV–Vis spectroscopy, FTIR, XRD, FESEM, EDX, and DLS analyses, confirming the formation of amorphous, high-purity SiO₂ nanoparticles with Si–O–Si and Si–OH functional groups. FESEM analysis revealed particle sizes of 50–200 nm, while DLS indicated a hydrodynamic diameter of 298.3 nm (PDI = 0.496). The nanoparticles exhibited significant antioxidant activity (96.7% DPPH scavenging at 10 µg/mL), concentration-dependent antimicrobial effects, notable anti-inflammatory activity (IC₅₀ = 165 µL), and moderate cytotoxicity against L929 fibroblast cells (IC₅₀ = 112.06 µg/mL). This study presents an eco-friendly strategy for producing biofunctionalized silica nanoparticles with promising applications in nanomedicine and antimicrobial therapy.