Scholarlink

<p>Colon cancer is the third most frequent malignancy globally and the second leading cause of cancer-related mortality. Natural compounds have proven to offer positive potential in the treatment of different carcinomas. Recent studies have demonstrated the strong anti-inflammatory and antioxidant properties of <i>Nardostachys jatamansi</i> root essential oil (NJ-EO). However, so far, there are only a few reports regarding the potential of this plant against various cancer cell lines, including colon cancer cells. Therefore, this work aimed to investigate the cytotoxic potential of NJ-EO on HCT-116 human colon cancer cells. According to the results, several mono- and sesquiterpene compounds were identified in the NJ-EO by GC-MS analysis on the basis of mass/charge ratio. Among the identified constituents, valeranone (29.76%) emerged as the most abundant compound, followed by tau-cadinol (23.25%) and patchouli alcohol (8.58%), all of which are sesquiterpenes with well-documented pharmacological properties. Moreover, the results of the MTT assay, cytomorphological and nuclear imaging, H2DCFDA, Rh123, JC-1 staining, etc., along with apoptosis and cell cycle analysis, showed significant cytotoxic activity of NJ-EO against HCT-116 cells, suggesting its potential in the prevention and management of colon cancer, which could be due to the abundance of terpenoids.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sesquiterpene-rich Root Essential Oil of Nardostachys jatamansi Exhibits Antiproliferative and Pro-apoptotic Activity in Colon Cancer Cells

  • 期刊论文

  • 发表日期：

    2026年3月26日

查看全文
  • Fariha Sumayya,
  • Shireen Fatima,
  • Uzma Shahab,
  • Saheem Ahmad,
  • Bodor Bin Sheeha,
  • Paridhi Puri,
  • Safia Obaidur Rab,
  • Omar W. Althomali,
  • Mohammed Haris Siddiqui,
  • Irfan Ahmad Ansari

摘要

Colon cancer is the third most frequent malignancy globally and the second leading cause of cancer-related mortality. Natural compounds have proven to offer positive potential in the treatment of different carcinomas. Recent studies have demonstrated the strong anti-inflammatory and antioxidant properties of Nardostachys jatamansi root essential oil (NJ-EO). However, so far, there are only a few reports regarding the potential of this plant against various cancer cell lines, including colon cancer cells. Therefore, this work aimed to investigate the cytotoxic potential of NJ-EO on HCT-116 human colon cancer cells. According to the results, several mono- and sesquiterpene compounds were identified in the NJ-EO by GC-MS analysis on the basis of mass/charge ratio. Among the identified constituents, valeranone (29.76%) emerged as the most abundant compound, followed by tau-cadinol (23.25%) and patchouli alcohol (8.58%), all of which are sesquiterpenes with well-documented pharmacological properties. Moreover, the results of the MTT assay, cytomorphological and nuclear imaging, H2DCFDA, Rh123, JC-1 staining, etc., along with apoptosis and cell cycle analysis, showed significant cytotoxic activity of NJ-EO against HCT-116 cells, suggesting its potential in the prevention and management of colon cancer, which could be due to the abundance of terpenoids.