<p>Synzymes, synthetic mimics of natural enzymes, have emerged as a promising frontier in modern biocatalysis due to their enhanced stability, adaptability, and catalytic performance. Unlike natural enzymes, synzymes are engineered to function under extreme physicochemical conditions, making them suitable for a broad range of applications in biomedicine, industrial biotechnology, and environmental remediation. This review provides a comprehensive overview of the structural principles, functional mechanisms, and real-world applications of synzymes. Particular attention is given to their role in targeted drug delivery, biosensing, green manufacturing, and pollutant degradation. Furthermore, the integration of artificial intelligence and high-throughput screening technologies has accelerated synzyme design, enabling more efficient and cost-effective development pipelines. By evaluating both the innovations and current limitations in synzyme research, this article outlines the growing potential of synthetic enzymes as next-generation tools for sustainable and precision-driven solutions.</p>