<p>This study aimed to optimize the structural performance of an automotive front-end frame (FEF), with a focus on enhancing its stiffness, strength, and modal properties. Initially, the baseline performance of the frame was evaluated through the finite element analysis (FEA), and critical weak regions were identified. Subsequently, the optimization process targeted the shape and wall thickness of stiffeners in the locked zone to improve the frame’s stiffness. A weighted trade-off planning method (TPM) was employed for comprehensive multi-objective optimization, and the weights of static flexibility and dynamic frequency were determined using the Grey Relational Analysis (GRA) and Analytic Hierarchy Process (AHP). The results indicated that stiffness within the locked zone was improved by 20.4% and 42.1% in the X and Z directions, respectively. The optimized frame is suitable for injection molding manufacturing, which effectively enhances product development efficiency.</p> Graphical Abstract <p></p>