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<p>Magnesium (Mg) and its alloys hold great promise for orthopedic application due to their biodegradability and mechanical compatibility with bone. However, their rapid degradation in physiological environments remains a significant barrier to clinical translation. This study presents a hybrid surface modification approach to reduce the degradation rate and improve the biocompatibility of AZ61 alloy. The alloy surface was pre-treated with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), which resulted in a rougher surface and enhanced adhesion with subsequent polymer coatings. A polycaprolactone (PCL) electrospun nanofiber coating was applied to both untreated (AZ61/PCL) and H<sub>2</sub>O<sub>2</sub> treated AZ61 alloy (AZ61ST/PCL) surface to assess the impact of surface pre-treatment. Surface morphology and composition of the specimen were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). Adhesion and interfacial bonding were evaluated using peel-off test. Electrochemical test, including open circuit potential (OCP), potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS), indicated the stability of PCL coating as well as significantly improved corrosion resistance in H<sub>2</sub>O<sub>2</sub>-treated and PCL-coated AZ61 surface. Immersion studies in simulated body fluid (SBF) solution and in-vitro cell culture studies using osteoblast cells confirmed enhanced cell adhesion, proliferation, and biocompatibility of the coating. The combined chemical surface treatment followed by nanofiber coating demonstrates significant potential for improving the functional performance and longevity of Mg-based orthopedic implants.</p>

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Electrospun PCL nanofiber coating on H2O2‐treated AZ61 magnesium alloy: an effective approach for coating adherence improvement and bio-functional orthopedic application

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Silpa Cheriyan,
  • M. Karthega

摘要

Magnesium (Mg) and its alloys hold great promise for orthopedic application due to their biodegradability and mechanical compatibility with bone. However, their rapid degradation in physiological environments remains a significant barrier to clinical translation. This study presents a hybrid surface modification approach to reduce the degradation rate and improve the biocompatibility of AZ61 alloy. The alloy surface was pre-treated with hydrogen peroxide (H2O2), which resulted in a rougher surface and enhanced adhesion with subsequent polymer coatings. A polycaprolactone (PCL) electrospun nanofiber coating was applied to both untreated (AZ61/PCL) and H2O2 treated AZ61 alloy (AZ61ST/PCL) surface to assess the impact of surface pre-treatment. Surface morphology and composition of the specimen were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). Adhesion and interfacial bonding were evaluated using peel-off test. Electrochemical test, including open circuit potential (OCP), potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS), indicated the stability of PCL coating as well as significantly improved corrosion resistance in H2O2-treated and PCL-coated AZ61 surface. Immersion studies in simulated body fluid (SBF) solution and in-vitro cell culture studies using osteoblast cells confirmed enhanced cell adhesion, proliferation, and biocompatibility of the coating. The combined chemical surface treatment followed by nanofiber coating demonstrates significant potential for improving the functional performance and longevity of Mg-based orthopedic implants.