<p>Films were prepared using chitosan and loess-based P-type molecular sieves as the primary raw materials, with modifications made using potassium diformate, hydroxy silicone oil, and other additives. Following a reaction under specific conditions and subsequent drying, an LMSC-film (loess-based molecular sieves and silicone oil-modified chitosan film) was obtained, exhibiting antibacterial, bactericidal, moisture-retaining, and biodegradable properties. The structural and physicochemical characteristics of the film were systematically analyzed. The results demonstrated that the modified film possessed a denser internal structure and a more compact surface morphology, along with an increased crosslinking degree. Notably, its thermal stability and hydrophobicity were significantly improved, achieving a maximum water contact angle of approximately 76°. Evaluations of mechanical properties revealed substantial enhancements: The modified film maintained high flexibility even after prolonged exposure to air, and its susceptibility to hardening and brittleness was reduced. Additionally, its water loss rate in ambient conditions was markedly lower, and it exhibited excellent aging resistance. Due to these favorable properties, the LMSC-film showed promising applications as a wound dressing to accelerate wound healing and related immune responses. It also holds potential as an edible antimicrobial coating to inhibit microbial proliferation and extend food shelf life. This study provides novel insights and methodologies for the development of advanced antimicrobial materials.</p>