<p>In this review study, we look at how nanomaterials can prevent biofouling in marine antifouling coatings, which have a significant influence on maritime vessels and structures. Nanomaterials with wide surfaces, improved reactivity, and mechanical robustness are excellent resources for creating innovative antifouling approaches. The study assesses a variety of new formulations, including metal oxide nanoparticles, carbon-based nanomaterials, polymeric nanocomposites, hybrid nanomaterials, and bioinspired designs, all of which are effective and durable against fouling. Furthermore, the processes behind nanomaterials' antifouling activity are discussed, as are the prospective uses of nanomaterial-based antifouling coatings, as well as the accompanying restrictions and challenges. Finally, the article outlines forthcoming research avenues, including the creation of multifunctional coatings and the utilization of sustainable, nonharmful nanomaterials. Through the fusion of state-of-the-art nanotechnology with pragmatic implementations, this review evidences the capacity of nanomaterial-based antifouling coatings to transform the maritime sector by offering more effective, economically feasible, and environmentally friendly solutions.</p>