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<p>Dip deposition is a widely used coating mechanism for vascular stent devices due to its cost-effectiveness and ability to control deposition parameters, coating morphology, and coating thickness. Yet, there has been little to no research published on the influence of deposition parameters for poly(D,L-lactide co-glycolic) acid (PLGA) coatings on nitinol. Concentration of PLGA solution, dip speed, number of coatings, dwell time, and drainage time were evaluated for their influence on coating thickness and defects. The parameters were optimized to achieve a coating thickness between 10 and 20 microns with minimal defects. Coating uniformity was primarily influenced by solution concentration, where increasing the solution concentration enhanced the uniformity. Through Face-Centered Central Composite Design experiments, the study found that coating thickness increased with increased dip speed, decreased number of coats, increased dwell time, and decreased drainage time. The optimal dip parameters were a 10&#xa0;w/v% PLGA solution matrix at 100&#xa0;mm/min, 30&#xa0;min dwell time, 1&#xa0;min drainage time, and 1 coating. The optimal coating showed a negligible Type III defect with a Type III coating after mechanical failure from tension testing. The results concluded that the optimized parameters for PLGA coatings on nitinol wires are sufficient for further research and development of PLGA coatings on nitinol stent.</p>

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The preparation of PLGA coating on nitinol wire for vascular stent applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月10日

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  • Baylie Phillips,
  • Sudhakar Vadiraja,
  • Richard LaDouceur,
  • Blaine Berrington

摘要

Dip deposition is a widely used coating mechanism for vascular stent devices due to its cost-effectiveness and ability to control deposition parameters, coating morphology, and coating thickness. Yet, there has been little to no research published on the influence of deposition parameters for poly(D,L-lactide co-glycolic) acid (PLGA) coatings on nitinol. Concentration of PLGA solution, dip speed, number of coatings, dwell time, and drainage time were evaluated for their influence on coating thickness and defects. The parameters were optimized to achieve a coating thickness between 10 and 20 microns with minimal defects. Coating uniformity was primarily influenced by solution concentration, where increasing the solution concentration enhanced the uniformity. Through Face-Centered Central Composite Design experiments, the study found that coating thickness increased with increased dip speed, decreased number of coats, increased dwell time, and decreased drainage time. The optimal dip parameters were a 10 w/v% PLGA solution matrix at 100 mm/min, 30 min dwell time, 1 min drainage time, and 1 coating. The optimal coating showed a negligible Type III defect with a Type III coating after mechanical failure from tension testing. The results concluded that the optimized parameters for PLGA coatings on nitinol wires are sufficient for further research and development of PLGA coatings on nitinol stent.