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<p>Grape pomace (<i>Vitis vinifera</i> L.) is a major by-product generated by vinification process. The valorization and re-utilization of grape pomace represents a strategy to improve waste management in wine-making industry. The objective of this study was to evaluate the potential of natural deep eutectic solvents (NADES), as novel green solvents, for the extraction and stabilization of bioactive compounds from Merlot grape pomace, with the aim to promote the re-use of winery by-products. Phytochemicals were extracted using NADES as green solvents, and reference solvents: 50% ethanol and acidified ethanol (50% ethanol/1% HCl) in combination with ultrasound (40 °C, 30 min, 37 kHz). Malvidin 3-glucoside was the major compound in extracts. Choline chloride:1,2-propanediol and choline chloride:glycerol NADES yielded more than 30% higher content of 3-glucosides of malvidin and pelargonidin compared to ethanol extraction. Ternary NADES composed of choline chloride, lactic acid, and 1,2-propanediol or urea showed the lowest IC<sub>50</sub> values in α-glucosidase inhibition assay and enhanced antioxidant activity (DPPH, FRAP, and ORAC) than other NADES and ethanol, but similar to acidified ethanol extract. NADES preserved the structure of phenolics better than reference solvents after 60 days of storage at + 4 °C. Results highlight NADES as effective solvents for the isolation of phytochemicals from grape pomace with enhanced bioactivity and stability.</p>

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Exploring Natural Deep Eutectic Solvents for Extraction and Stabilization of Grape Pomace Phytochemicals

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Tatjana Jurić,
  • Sara Hourani,
  • Milica Petković,
  • Jelena Vukosavljević,
  • Ružica Ždero Pavlović,
  • Branimir Pavlić,
  • Boris M. Popović

摘要

Grape pomace (Vitis vinifera L.) is a major by-product generated by vinification process. The valorization and re-utilization of grape pomace represents a strategy to improve waste management in wine-making industry. The objective of this study was to evaluate the potential of natural deep eutectic solvents (NADES), as novel green solvents, for the extraction and stabilization of bioactive compounds from Merlot grape pomace, with the aim to promote the re-use of winery by-products. Phytochemicals were extracted using NADES as green solvents, and reference solvents: 50% ethanol and acidified ethanol (50% ethanol/1% HCl) in combination with ultrasound (40 °C, 30 min, 37 kHz). Malvidin 3-glucoside was the major compound in extracts. Choline chloride:1,2-propanediol and choline chloride:glycerol NADES yielded more than 30% higher content of 3-glucosides of malvidin and pelargonidin compared to ethanol extraction. Ternary NADES composed of choline chloride, lactic acid, and 1,2-propanediol or urea showed the lowest IC50 values in α-glucosidase inhibition assay and enhanced antioxidant activity (DPPH, FRAP, and ORAC) than other NADES and ethanol, but similar to acidified ethanol extract. NADES preserved the structure of phenolics better than reference solvents after 60 days of storage at + 4 °C. Results highlight NADES as effective solvents for the isolation of phytochemicals from grape pomace with enhanced bioactivity and stability.