Purpose of Review <p>This article provides an overview of strategies to biofabricate functional cardiac patch devices to treat damaged myocardium, with a focus on recent advances on 3D bioprinted patch constructs.</p> Recent Findings <p>Cardiac patches have been developed to promote regeneration of the myocardium after ischemic injuries. Recent studies strive to biofabricate functionalized cardiac patches that more closely mimic the native myocardium through the incorporation of vasculature, heterogenous cells and biomaterials, as well as various bioactive molecules. 3D bioprinting has enabled highly controlled assembly of cells and biomaterials. Leveraging the unique advantages of 3D bioprinting, fabricated patch devices can overcome the key challenges associated with traditional methods of cardiac tissue engineering.</p> Summary <p>Integration of materials science, stem cell technology, and 3D bioprinting has provided a unique opportunity to design and optimize a novel generation of functional patch constructs that could revolutionize the future of cardiovascular tissue engineering and regenerative medicine.</p>