Scholarlink

Purpose of Review <p>The purpose of this review is to highlight relevant literature on the epidemiology and pathophysiology of renal cell carcinoma with a tumor thrombus (RCC-TT), metastatic management, and the role of systemic therapy (ST).</p> Recent Findings <p>Current research indicates different prevalences and presentations by geography, with many classification systems for RCC-TT. Pathophysiology remains poorly understood for TT formation. Some patients may benefit from cytoreductive nephrectomy with tumor thrombectomy (CN-TT) as well as ST administration, but this population is poorly defined.</p> Summary <p>RCC-TT is a complex disease to manage and lacks high-powered publications relative to RCC without a TT. Future research should focus on the genetics behind TT formation and propagation, CN-TT outcomes, and which patients should receive ST and the optimal timing/dosage.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Reviewing the Current State of Renal Cell Carcinoma with a Tumor Thrombus: Epidemiology, Pathophysiology, Metastasis, and Systemic Therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月1日

查看全文
  • Maxwell Sandberg,
  • Randall Bissette,
  • Kimberly Waggener,
  • Gaetano Ciancio,
  • Alejandro R. Rodriguez

摘要

Purpose of Review

The purpose of this review is to highlight relevant literature on the epidemiology and pathophysiology of renal cell carcinoma with a tumor thrombus (RCC-TT), metastatic management, and the role of systemic therapy (ST).

Recent Findings

Current research indicates different prevalences and presentations by geography, with many classification systems for RCC-TT. Pathophysiology remains poorly understood for TT formation. Some patients may benefit from cytoreductive nephrectomy with tumor thrombectomy (CN-TT) as well as ST administration, but this population is poorly defined.

Summary

RCC-TT is a complex disease to manage and lacks high-powered publications relative to RCC without a TT. Future research should focus on the genetics behind TT formation and propagation, CN-TT outcomes, and which patients should receive ST and the optimal timing/dosage.