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Purpose of Review <p>This review critically evaluates the claim that etiology is not relevant to cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD). Research on the clinical presentation and treatment outcomes associated with traumatic/stressor and biological etiologies is presented.</p> Recent Findings <p>The extant literature demonstrates varying clinical utility across the reviewed etiologies. Traumatic/stressor etiologies show the most consistent and robust evidence of clinical utility, demonstrating compelling associations with clinical presentation and treatment outcomes, while also being amenable to existing evidence-based approaches. Medical conditions (e.g., Pediatric Acute onset Neuropsychiatric Syndrome) and neurobiological factors also demonstrate considerable associations with OCD presentation, yet effective treatments are more variable. Genetics research is still emerging, with unclear clinical utility based on presently available treatments.</p> Summary <p>Etiology has variable clinical utility for OCD. We argue that some etiological mechanisms become maintenance factors that are relevant treatment targets, and call for continued research in these emerging domains.</p>

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“It Doesn’t Matter Where OCD Comes From,” or Does It?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月30日

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  • Caitlin M. Pinciotti,
  • Ryan J. McCarty,
  • Gabriella T. Ponzini

摘要

Purpose of Review

This review critically evaluates the claim that etiology is not relevant to cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD). Research on the clinical presentation and treatment outcomes associated with traumatic/stressor and biological etiologies is presented.

Recent Findings

The extant literature demonstrates varying clinical utility across the reviewed etiologies. Traumatic/stressor etiologies show the most consistent and robust evidence of clinical utility, demonstrating compelling associations with clinical presentation and treatment outcomes, while also being amenable to existing evidence-based approaches. Medical conditions (e.g., Pediatric Acute onset Neuropsychiatric Syndrome) and neurobiological factors also demonstrate considerable associations with OCD presentation, yet effective treatments are more variable. Genetics research is still emerging, with unclear clinical utility based on presently available treatments.

Summary

Etiology has variable clinical utility for OCD. We argue that some etiological mechanisms become maintenance factors that are relevant treatment targets, and call for continued research in these emerging domains.