Purpose of Review <p> This review considers the available research testing the efficacy of self-guided psychotherapeutic interventions in the management of affective premenstrual disorder (PMD) symptoms. </p> Recent Findings <p> Recent research confirms that clinician-guided internet-delivered cognitive behavior therapy is effective for the management of PMD symptoms. There is also mounting research suggesting that self-guided psychotherapy interventions are effective for a range of mental health conditions when featuring specific design elements aimed at enhancing engagement and learning.</p> Summary <p> Self-guided psychotherapeutic interventions hold promise for the treatment of PMD symptoms. Integrating such interventions within existing menstrual cycle tracking mobile applications may increase access to affordable and effective mental healthcare. Further research in this area is warranted.</p>