Purpose of Review <p>To compare quadratus lumborum block (QLB) and epidural block for postoperative analgesia in urologic surgeries, focusing on clinical efficacy, safety, and practical technique selection within contemporary perioperative care.</p> Recent Findings <p>This narrative, literature-based comparative analysis synthesized five single-center randomized controlled trials and related secondary analyses published between 2019 and 2025 that directly compared QLB with epidural block for common urologic procedures, together with recent systematic reviews and meta-analyses. Across radical cystectomy and laparoscopic nephrectomy, posterior and anterior QLB generally provided postoperative pain scores and opioid consumption comparable to epidural block, with several trials reporting more stable hemodynamics, fewer vasopressor interventions, and lower rates of postoperative nausea in QLB groups. In open partial nephrectomy, continuous subcostal anterior QLB did not meet prespecified non-inferiority margins for opioid consumption or pain scores relative to continuous epidural block. The available evidence is limited by small sample sizes, heterogeneity in block techniques and epidural protocols, and a predominant focus on short-term outcomes.</p> Conclusion <p>Current randomized data suggest that QLB is a useful alternative to epidural block for postoperative pain management in selected urologic procedures, particularly when neuraxial techniques are less desirable or contraindicated, whereas epidural block remains the benchmark for more extensive open flank surgery. Technique selection should be individualized according to procedure type, patient comorbidities, and institutional expertise. Larger, standardized multicenter trials are needed to clarify the relative roles of QLB and epidural block within enhanced recovery pathways for urologic surgery.</p>