Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential

期刊论文
发表日期：

2024年4月23日

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Yanchen Feng,
Xue Dang,
Pan Zheng,
Yali Liu,
Diyan Liu,
Zhiying Che,
Jianping Yao,
Zixuan Lin,
Ziyun Liao,
Xingyuan Nie,
Feixiang Liu,
Yunke Zhang

摘要

Purpose of Review

This review aims to provide a theoretical basis and insights for quercetin’s clinical application in the prevention and treatment of osteoporosis (OP), analyzing its roles in bone formation promotion, bone resorption inhibition, anti-inflammation, antioxidant effects, and potential mechanisms.

Recent Findings

OP, a prevalent bone disorder, is marked by reduced bone mineral density and impaired bone architecture, elevating the risk of fractures in patients. The primary approach to OP management is pharmacotherapy, with quercetin, a phytochemical compound, emerging as a focus of recent interest. This natural flavonoid exerts regulatory effects on bone marrow mesenchymal stem cells, osteoblasts, and osteoclasts and promotes bone health and metabolic equilibrium via anti-inflammatory and antioxidative pathways.

Summary

Although quercetin has demonstrated significant potential in regulating bone metabolism, there is a need for further high-quality clinical studies focused on medicinal quercetin.