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Purpose of Review <p>Hypercalcemia of malignancy is one of the most common metabolic disorders in patients with cancer and is associated with significant morbidity and mortality. This narrative review summarizes pathophysiology, clinical presentation, diagnostic strategies, and therapies available for the management of hypercalcemia of malignancy in acutely ill adult patients.</p> Recent Findings <p>We reviewed both classic and recent literature to provide practical recommendations for managing cancer-related hypercalcemia. Our findings are presented in the context of recently published societal guidelines.</p> Summary <p>Timely identification and treatment of acute hypercalcemia of malignancy is vital. Understanding of the underlying disease processes and available therapies is needed to optimize patient care and healthcare resource utilization.</p>

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Acute Management of Hypercalcemia of Malignancy – A Review of Pathophysiology, Diagnosis, and Treatment

  • 期刊论文

  • 发表日期：

    2025年5月28日

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  • Ashley Crouch,
  • Aysha Chaudhri,
  • Sonya Khan,
  • Maggie Ma,
  • Ngoc Vu,
  • William Towers

摘要

Purpose of Review

Hypercalcemia of malignancy is one of the most common metabolic disorders in patients with cancer and is associated with significant morbidity and mortality. This narrative review summarizes pathophysiology, clinical presentation, diagnostic strategies, and therapies available for the management of hypercalcemia of malignancy in acutely ill adult patients.

Recent Findings

We reviewed both classic and recent literature to provide practical recommendations for managing cancer-related hypercalcemia. Our findings are presented in the context of recently published societal guidelines.

Summary

Timely identification and treatment of acute hypercalcemia of malignancy is vital. Understanding of the underlying disease processes and available therapies is needed to optimize patient care and healthcare resource utilization.