CGRP Modulating Therapies: An Update

Calcitonin-gene related peptide (CGRP) is a vasoactive neuropeptide involved in the pathophysiology ofmigraine. CGRP has been targeted for both preventive and acute treatment of migraine.

Provide a summary of the most clinically relevant literature surrounding CGRP modulating therapies.

This update on CGRP modulating therapies includes articles selected as most clinically relevant by theauthors.

CGRP modulating therapies are an exciting new addition to migraine treatment given their safety andtolerability. Additionally, compared to traditional migraine preventive medication these treatments are migrainespecific.Further real-world and clinical data is ongoing to better understand these treatments that continue to gainfavor in the management of migraine.