Effect of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: An Updated Meta-analysis

The effect of continuous positive airway pressure (CPAP) on resistant hypertension in patients at high risk with obstructive sleep apnea (OSA) needs further investigation. We aimed to determine the effect of CPAP on blood pressure in patients with resistant hypertension and OSA. Databases including PubMed, EMBASE, MEDLINE, the Cochrane Library, and CMB were searched. Data were pooled using a random-effects or fixed-effects model to derive weighted mean differences (WMDs) and 95% confidence intervals (CIs).

A total of 12 trials and 718 participants were included. Compared with control, CPAP significantly reduced 24-h systolic blood pressure (SBP) (WMD: − 5.92 mmHg [ − 8.72, − 3.11]; P＜0.001), 24-h diastolic blood pressure (DBP) (WMD: − 4.44 mmHg [− 6.26 , − 2.62]; P  ＜0.001),   daytime SBP (WMD: − 5.76 mmHg [ − 9.16,  − 2.36]; P ＜0.001),  daytime DBP (WMD: − 3.92 mmHg [− 5.55,  − 2.30];  nighttime SBP (WMD: − 4.87 mmHg [ − 7.96 ,  − 1.78]; P = 0.002), and nighttime DBP (WMD: − 2.05 mmHg [− 2.99,  − 1.11]; P＜0.001) in patients with resistant hypertension and OSA. CPAP improved the blood pressure both in the short (＜3 months) and long term (≥ 3  months). No significant impact on mean heart rate was noted (WMD: -2.76 beats per min [− 7.50, 1.97]; P = 0.25).

CPAP treatment was associated with BP reduction in patients with resistant hypertension and OSA.