Scholarlink

Purpose of Review <p>We aim to provide a mechanistic review of available anti-emetic medications along with practical strategies of use and future areas of study in patients with cirrhosis.</p> Recent Findings <p>There is a dearth of liver-specific data for most, if not all, antiemetic medications in patients with cirrhosis. Of medications available, 5HT3 antagonists, prokinetics, and atypical antipsychotics carry targeted roles and favorable risk profiles when appropriately dosed. Other pharmacologic therapies (e.g. prucalopride) carry promising potential but require further study. Some nonpharmacologic therapies (e.g. aromatherapy, acupuncture) may carry practical benefit with minimal risk and cost.</p> Summary <p>Nausea and vomiting is a common symptom in the illness trajectory of cirrhosis with minimal to no liver-specific outcomes data on many of our anti-emetic medications. At this time, safe and educated treatment of nausea and vomiting requires familiarity with basic pharmacologic mechanisms, acknowledgement of gaps in data, and intentional discussions with patients regarding risks and goals of therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Best Practices, Resources and Innovations: A Mechanistic Review of Nausea and Vomiting Management Options in Cirrhosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月26日

查看全文
  • Claudio Roberto Tombazzi,
  • Sara F. Martin

摘要

Purpose of Review

We aim to provide a mechanistic review of available anti-emetic medications along with practical strategies of use and future areas of study in patients with cirrhosis.

Recent Findings

There is a dearth of liver-specific data for most, if not all, antiemetic medications in patients with cirrhosis. Of medications available, 5HT3 antagonists, prokinetics, and atypical antipsychotics carry targeted roles and favorable risk profiles when appropriately dosed. Other pharmacologic therapies (e.g. prucalopride) carry promising potential but require further study. Some nonpharmacologic therapies (e.g. aromatherapy, acupuncture) may carry practical benefit with minimal risk and cost.

Summary

Nausea and vomiting is a common symptom in the illness trajectory of cirrhosis with minimal to no liver-specific outcomes data on many of our anti-emetic medications. At this time, safe and educated treatment of nausea and vomiting requires familiarity with basic pharmacologic mechanisms, acknowledgement of gaps in data, and intentional discussions with patients regarding risks and goals of therapy.