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Purpose of Review <p>The aim of this review is to evaluate the evolving burden of cardiovascular disease (CVD) between 2025 and 2050.</p> Recent Findings <p>Between 1990–2023, CVD deaths increased from 13.1 million to 19.2 million, with prevalence rising from 311 to 626 million cases. Most CVD burden is attributable to modifiable risk factors, led by high systolic blood pressure (SBP).</p> Summary <p>By 2050, CVD mortality will reach 35.6 million deaths annually, while prevalence will be at 1.14 billion cases globally. Metabolic, environmental and behavioral determinants will be key drivers, varying across regions according to sociodemographic index. Age-standardized mortality rates will decline, but absolute numbers of people living with CVD will rise due to population growth, aging, and possibly also improved access to care, especially in low-middle income countries. Prevention strategies, early detection and treatment, and better implementation of what is already known are necessary to address this burden.</p>

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Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?

  • 期刊论文

  • 发表日期：

    2026年3月14日

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  • Unaiza Naeem,
  • Salil Deo,
  • Amirhossein Sahebkar,
  • Sana Sheikh,
  • Adeel Khoja,
  • Elizabeth M. Vaughan,
  • Ali bin Abdul Jabbar,
  • Dinesh K. Kalra,
  • Leandro Slipczuk,
  • Salim Shahbuddin Virani

摘要

Purpose of Review

The aim of this review is to evaluate the evolving burden of cardiovascular disease (CVD) between 2025 and 2050.

Recent Findings

Between 1990–2023, CVD deaths increased from 13.1 million to 19.2 million, with prevalence rising from 311 to 626 million cases. Most CVD burden is attributable to modifiable risk factors, led by high systolic blood pressure (SBP).

Summary

By 2050, CVD mortality will reach 35.6 million deaths annually, while prevalence will be at 1.14 billion cases globally. Metabolic, environmental and behavioral determinants will be key drivers, varying across regions according to sociodemographic index. Age-standardized mortality rates will decline, but absolute numbers of people living with CVD will rise due to population growth, aging, and possibly also improved access to care, especially in low-middle income countries. Prevention strategies, early detection and treatment, and better implementation of what is already known are necessary to address this burden.