Purpose of Review <p>To highlight important recent findings demonstrating the interconnectedness of planetary and human health with a focus on cardiovascular disease.</p> Recent Findings <p>Data continue to demonstrate a clear interconnectedness between the health of the planet and human health, with cardiovascular disease as an important outcome. The central roles of air pollution, non-optimal temperatures, water/waste management, and food/biodiversity are highlighted. We also highlight the clear opportunity for healthcare organizations to facilitate change that will yield positive environmental and patient outcomes.</p> Summary <p>The undeniable interconnectedness of the health of the planet and human health serves as a call to action for physicians, scientists, and policy makers to implement change that will lead to sustainability, a reduction in pollution, and a step into a better future.</p>