Purpose of Review <p>To provide a review of current transcatheter structural heart interventions in women, with a focus on sex-specific considerations in diagnosis, treatment and outcomes.</p> <Emphasis Type="Underline">Recent</Emphasis> Findings <p>Transcatheter interventions have transformed structural heart disease treatment, including valvular heart disease and left atrial appendage closure. Historically, low female enrollment in cardiovascular trials has limited sex-specific data integration into clinical guidelines. Recently, the changing landscape of female representation has provided insight into distinct pathophysiology, high-risk features, clinical characteristics, disease surveillance, referral barriers, and treatment responses.</p> Summary <p>The success of transcatheter structural heart interventions relies on judicious patient selection and timely intervention. This review evaluates contemporary female representation in transcatheter studies, highlighting sex-specific prevalence, anatomic and physiologic variations, clinical presentations and both short- and long-term outcomes. Knowledge gaps and future research directions are identified to address diagnostic and therapeutic disparities, ultimately improving individualized lifetime care in women with structural heart disease.</p>