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Purpose of review <p>This review summarizes the rationale as well as published data for GAG substitution therapy in chronic bladder diseases, primarily in bladder pain syndrome/interstitial cystitis (BPS/IC).</p> Recent findings <p>The beneficial effect of GAG substitution therapy is well documented in many studies, however in mostly uncontrolled settings. Symptom remission rates vary in a wide range between 40 and 94%, which reflects the mostly inhomogeneous patient groups.</p> Summary <p>Phenotyping of BPS/IC patients is assumed to be the key point to increase efficacy of GAG substitution therapy that should be dedicated to patients with bladder-centric phenotype.</p>

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Effects of GAG Therapy on Urothelial Barrier and Repair

  • 期刊论文

  • 发表日期：

    2026年5月1日

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  • Andreas Bruchbacher,
  • Claus Riedl

摘要

Purpose of review

This review summarizes the rationale as well as published data for GAG substitution therapy in chronic bladder diseases, primarily in bladder pain syndrome/interstitial cystitis (BPS/IC).

Recent findings

The beneficial effect of GAG substitution therapy is well documented in many studies, however in mostly uncontrolled settings. Symptom remission rates vary in a wide range between 40 and 94%, which reflects the mostly inhomogeneous patient groups.

Summary

Phenotyping of BPS/IC patients is assumed to be the key point to increase efficacy of GAG substitution therapy that should be dedicated to patients with bladder-centric phenotype.