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Purpose of Review <p>This review describes the recently developed equations for calculating Low-density lipoprotein cholesterol (LDL-C), and equations for estimating small dense LDL-cholesterol (sdLDL-C), and LDL-triglycerides (LDL-TG) for atherosclerotic cardiovascular disease (ASCVD) risk assessment.</p> Recent Findings <p>The new Modified Sampson-NIH equation provides a more accurate estimation of LDL-C across a wide range of TG levels compared to the traditional and still commonly used Friedewald equation. Furthermore, it is more accurate compared to other equations at the low LDL-C cutpoints used for high-risk and very high-risk ASCVD patients and is valuable for deciding the need for additional lipid-lowering therapy. New equations for calculating sdLDL-C and LDL-TG use the same lipid parameters as for calculating LDL-C but offer additional insights into atherogenic lipoprotein burden.</p> Summary <p>High plasma TG and very low LDL-C concentrations necessitate more accurate LDL-C calculations, which can be readily adopted without additional cost to improve ASCVD risk management.</p>

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New Methods for Calculating LDL-Cholesterol and Related Biomarkers of Atherosclerotic Cardiovascular Disease Risk

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月25日

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  • Anna Wolska,
  • Yeganeh Mansourian,
  • Rafael Zubirán,
  • Maureen Sampson,
  • Alan T. Remaley

摘要

Purpose of Review

This review describes the recently developed equations for calculating Low-density lipoprotein cholesterol (LDL-C), and equations for estimating small dense LDL-cholesterol (sdLDL-C), and LDL-triglycerides (LDL-TG) for atherosclerotic cardiovascular disease (ASCVD) risk assessment.

Recent Findings

The new Modified Sampson-NIH equation provides a more accurate estimation of LDL-C across a wide range of TG levels compared to the traditional and still commonly used Friedewald equation. Furthermore, it is more accurate compared to other equations at the low LDL-C cutpoints used for high-risk and very high-risk ASCVD patients and is valuable for deciding the need for additional lipid-lowering therapy. New equations for calculating sdLDL-C and LDL-TG use the same lipid parameters as for calculating LDL-C but offer additional insights into atherogenic lipoprotein burden.

Summary

High plasma TG and very low LDL-C concentrations necessitate more accurate LDL-C calculations, which can be readily adopted without additional cost to improve ASCVD risk management.