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Purpose of Review <p>Coronary heart disease (CHD) is a major global threat to human health. This review summarizes the latest progress of metabolomics in CHD research, and provides insights into the pathogenesis and identify dependable biomarkers of CHD.</p> Recent Findings <p>This review has summarized 303 metabolic indicators related to CHD, with a focus on 53 biomarkers, and highlighted the top 10 biomarkers with significant clinical value. The biosynthesis of unsaturated fatty acids, amino acids, and aminoacyl-tRNA, as well as amino acid metabolism, are linked to CHD pathogenesis.</p> Summary <p>Amino acids and lipids play essential roles in understanding the onset and progression of CHD. This review provides a new perspective on enhancing our understanding of CHD pathogenesis and developing effective treatment interventions.</p> Graphical Abstract <p></p>

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Recent Advances and Perspectives of Metabolomics-Based Investigations in Coronary Heart Disease

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Jianping Hu,
  • Jiaxin Zhou,
  • Yong Liang,
  • Xiaotian Chen,
  • Hongdong Liu,
  • Bin Li,
  • Luqi Huang

摘要

Purpose of Review

Coronary heart disease (CHD) is a major global threat to human health. This review summarizes the latest progress of metabolomics in CHD research, and provides insights into the pathogenesis and identify dependable biomarkers of CHD.

Recent Findings

This review has summarized 303 metabolic indicators related to CHD, with a focus on 53 biomarkers, and highlighted the top 10 biomarkers with significant clinical value. The biosynthesis of unsaturated fatty acids, amino acids, and aminoacyl-tRNA, as well as amino acid metabolism, are linked to CHD pathogenesis.

Summary

Amino acids and lipids play essential roles in understanding the onset and progression of CHD. This review provides a new perspective on enhancing our understanding of CHD pathogenesis and developing effective treatment interventions.

Graphical Abstract