Scholarlink

Purpose of Review <p>Central Compartment Atopic Disease (CCAD) is an emerging phenotype of chronic rhinosinusitis. The absence of a standardized diagnostic framework and the presence of heterogeneous reported characteristics underscore the importance of consolidating current knowledge on CCAD. This review aims to enhance understanding of the CCAD phenotype by focusing on its clinical and radiologic features, its association with inhalant allergies, and its therapeutic implications in comparison with other chronic rhinosinusitis phenotypes.</p> Methods <p>A systematic review was conducted through searches in five databases from 2017 to June 2025 following SWiM guidelines. The methodological quality and risk of bias of the included studies were evaluated using the Oxford Centre for Evidence-Based Medicine criteria. Data were analyzed using descriptive and qualitative synthesis.</p> Results <p>Seventeen studies were included for qualitative synthesis. CCAD diagnosis relied mainly on endoscopic and radiologic findings, often supported by allergy testing. Most patients showed lower rates of asthma, with variable allergic sensitization rates across populations and elevated blood and tissue eosinophils. Compared to other phenotypes, CCAD showed milder disease and favorable outcomes after endoscopic sinus surgery.</p> Conclusion <p>CCAD presents unique clinical and immunologic features that differ from other chronic rhinosinusitis subtypes. Standardized diagnostic criteria are needed to improve recognition and guide tailored management strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phenotypic Features of Central Compartment Atopic Disease Compared with Other Types of Chronic Rhinosinusitis: A Systematic Review

  • 期刊论文

  • 发表日期：

    2025年10月7日

查看全文
  • Julissa Vizcarra-Melgar,
  • Ramón Moreno-Luna,
  • Daniel Martín-Jiménez,
  • Concepción Gago-Torres,
  • Carmen Palma-Martínez,
  • Miriam González-García,
  • Lucía Prieto-Sánchez De Puerta,
  • Meritxell Clarí-Comes,
  • Jaime González-García,
  • Pedro Infante-Cossío,
  • Serafín Sánchez-Gómez

摘要

Purpose of Review

Central Compartment Atopic Disease (CCAD) is an emerging phenotype of chronic rhinosinusitis. The absence of a standardized diagnostic framework and the presence of heterogeneous reported characteristics underscore the importance of consolidating current knowledge on CCAD. This review aims to enhance understanding of the CCAD phenotype by focusing on its clinical and radiologic features, its association with inhalant allergies, and its therapeutic implications in comparison with other chronic rhinosinusitis phenotypes.

Methods

A systematic review was conducted through searches in five databases from 2017 to June 2025 following SWiM guidelines. The methodological quality and risk of bias of the included studies were evaluated using the Oxford Centre for Evidence-Based Medicine criteria. Data were analyzed using descriptive and qualitative synthesis.

Results

Seventeen studies were included for qualitative synthesis. CCAD diagnosis relied mainly on endoscopic and radiologic findings, often supported by allergy testing. Most patients showed lower rates of asthma, with variable allergic sensitization rates across populations and elevated blood and tissue eosinophils. Compared to other phenotypes, CCAD showed milder disease and favorable outcomes after endoscopic sinus surgery.

Conclusion

CCAD presents unique clinical and immunologic features that differ from other chronic rhinosinusitis subtypes. Standardized diagnostic criteria are needed to improve recognition and guide tailored management strategies.