Scholarlink

<p>This study explored the immunological effects of particulate matter (PM) exposure in individuals with allergies. It aimed to assess how ambient particulate matter influences humoral immunity and systemic inflammation. A total of 37 non-smoking allergic volunteers participated, grouped by high and low PM exposure periods. Peripheral blood samples were analyzed for antibodies against non-specific PM-components and inflammatory markers. IgE levels against non-specific PM components were significantly elevated during high PM periods, indicating acute immune activation. Conversely, IgG levels against non-specific PM components were higher at lower PM exposure levels. Among inflammation markers, PLR and SII increased with higher PM, while NLPR decreased. However, hsCRP showed a positive correlation with several indices under high PM conditions. The study also highlights PM role in immune system dysregulation and inflammation in allergic individuals. Monitoring antibody and inflammatory profiles may help identify individuals at greater risk. Further studies are needed to confirm these findings and clarify the mechanisms involved.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Airborne particulate matter exposure modulates humoral immune response and systemic inflammation in allergic individuals

  • 期刊论文

  • 发表日期：

    2026年4月17日

查看全文
  • José Francisco Zambrano Zaragoza ,
  • Juan C. Hernandez,
  • Iris Celeste Tovar Ocampo,
  • Aurora Elizabeth Rojas García ,
  • Irma Martha Medina Díaz,
  • Yael Yvette Bernal Hernández,
  • Cyndia Azucena González Arias,
  • Briscia Socorro Barrón Vivanco,
  • Bruno Daniel Bañuelos Pacheco,
  • Juan Manuel Agraz Cibrian

摘要

This study explored the immunological effects of particulate matter (PM) exposure in individuals with allergies. It aimed to assess how ambient particulate matter influences humoral immunity and systemic inflammation. A total of 37 non-smoking allergic volunteers participated, grouped by high and low PM exposure periods. Peripheral blood samples were analyzed for antibodies against non-specific PM-components and inflammatory markers. IgE levels against non-specific PM components were significantly elevated during high PM periods, indicating acute immune activation. Conversely, IgG levels against non-specific PM components were higher at lower PM exposure levels. Among inflammation markers, PLR and SII increased with higher PM, while NLPR decreased. However, hsCRP showed a positive correlation with several indices under high PM conditions. The study also highlights PM role in immune system dysregulation and inflammation in allergic individuals. Monitoring antibody and inflammatory profiles may help identify individuals at greater risk. Further studies are needed to confirm these findings and clarify the mechanisms involved.