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<p>In the treatment plan of breast cancer-related Cancer-related fatigue(CRF), non-drug intervention is the core, and physical exercise can improve the physical fitness and fatigue state of patients. Personalized nutritional support can correct energy imbalance and relieve malnutrition related fatigue. Psychological intervention such as cognitive behavioral therapy can regulate neuroendocrine and inflammatory responses and reduce fatigue induced by psychological factors, and the effect of multimodal combined intervention is better than that of single measure.However, there are some areas that can be optimized. First, drug therapy is rarely mentioned, and drug intervention for patients with moderate to severe CRF is not explored. Second, the characteristics of CRF in different breast cancer subtypes are different, and the existing protocols do not fully reflect the subtype specificity. Third, the adaptation of the intervention in the scenario of primary medical care is insufficient. Telemedicine and wearable devices can be combined to improve the accessibility of the program. In the future, it is necessary to further improve the synergistic mechanism of drugs and non-drugs and refine the subtype-specific scheme to achieve more accurate management of CRF.</p>

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Understanding, Recognizing, and Managing Cancer-Related Fatigue Associated with Breast Cancer

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • LanQing Peng,
  • XiaoMin Wang,
  • ChenRu Zhang,
  • Tao Liu,
  • Xin Luo,
  • ZhuoHong Li

摘要

In the treatment plan of breast cancer-related Cancer-related fatigue(CRF), non-drug intervention is the core, and physical exercise can improve the physical fitness and fatigue state of patients. Personalized nutritional support can correct energy imbalance and relieve malnutrition related fatigue. Psychological intervention such as cognitive behavioral therapy can regulate neuroendocrine and inflammatory responses and reduce fatigue induced by psychological factors, and the effect of multimodal combined intervention is better than that of single measure.However, there are some areas that can be optimized. First, drug therapy is rarely mentioned, and drug intervention for patients with moderate to severe CRF is not explored. Second, the characteristics of CRF in different breast cancer subtypes are different, and the existing protocols do not fully reflect the subtype specificity. Third, the adaptation of the intervention in the scenario of primary medical care is insufficient. Telemedicine and wearable devices can be combined to improve the accessibility of the program. In the future, it is necessary to further improve the synergistic mechanism of drugs and non-drugs and refine the subtype-specific scheme to achieve more accurate management of CRF.