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Background <p>Premature coronary artery disease (PCAD) is marked by accelerated progression of atherosclerosis, an increased incidence of adverse cardiovascular events, and a less favorable long-term prognosis.</p> Aims <p>The diagnostic potential and mechanistic basis of serum miR-20b-5p in PCAD.</p> Methods <p>Serum levels of miR-20b-5p, sd-LDL indicators (including particle number, concentration, proportion), and LDL particle diameter were measured. Logistic regression identified risk factors for coronary stenosis severity. Spearman analysis assessed the association between miR-20b-5p and Gensini score. ROC curve analysis evaluated clinical diagnostic utility of miR-20b-5p. Cell experiments validated the regulatory interaction between miR-20b-5p and CCL1, and their effects on oxidative stress and inflammation.</p> Results <p>The sd-LDL index and miR-20b-5p levels were significantly altered in patients with PCAD. Furthermore, miR-20b-5p levels and sd-LDL particle count were also associated with the severity of coronary stenosis.Serum levels of miR-20b-5p showed a significant negative correlation with the Gensini score and could serve as a diagnostic biomarker. miR-20b-5p directly targeted and inhibited CCL1, and its overexpression attenuated ox-LDL-induced oxidative stress and inflammatory reactions in HCAECs.</p> Conclusions <p>miR-20b-5p and abnormal small dense low-density lipoprotein are risk factors for evaluating the severity of coronary artery stenosis. Moreover, miR-20b-5p may alleviate vascular endothelial oxidative stress and inflammation by targeting CCL1, making it a potential therapeutic target for early intervention.</p>

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The diagnostic value and mechanistic role of miR-20b-5p in premature coronary artery disease

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Shizhao Hou,
  • Ao Liu,
  • Rongguo Sun,
  • Guangli Zhan,
  • Wei Zhang,
  • Zhihao Guo,
  • Ming Zhao,
  • Guowei Jia,
  • Wei Li

摘要

Background

Premature coronary artery disease (PCAD) is marked by accelerated progression of atherosclerosis, an increased incidence of adverse cardiovascular events, and a less favorable long-term prognosis.

Aims

The diagnostic potential and mechanistic basis of serum miR-20b-5p in PCAD.

Methods

Serum levels of miR-20b-5p, sd-LDL indicators (including particle number, concentration, proportion), and LDL particle diameter were measured. Logistic regression identified risk factors for coronary stenosis severity. Spearman analysis assessed the association between miR-20b-5p and Gensini score. ROC curve analysis evaluated clinical diagnostic utility of miR-20b-5p. Cell experiments validated the regulatory interaction between miR-20b-5p and CCL1, and their effects on oxidative stress and inflammation.

Results

The sd-LDL index and miR-20b-5p levels were significantly altered in patients with PCAD. Furthermore, miR-20b-5p levels and sd-LDL particle count were also associated with the severity of coronary stenosis.Serum levels of miR-20b-5p showed a significant negative correlation with the Gensini score and could serve as a diagnostic biomarker. miR-20b-5p directly targeted and inhibited CCL1, and its overexpression attenuated ox-LDL-induced oxidative stress and inflammatory reactions in HCAECs.

Conclusions

miR-20b-5p and abnormal small dense low-density lipoprotein are risk factors for evaluating the severity of coronary artery stenosis. Moreover, miR-20b-5p may alleviate vascular endothelial oxidative stress and inflammation by targeting CCL1, making it a potential therapeutic target for early intervention.