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Introduction <p>Methanol intoxication is a significant public health issue that can lead to serious complications such as metabolic acidosis and methanol-induced optic neuropathy. Early diagnosis is critical for reducing permanent vision loss and mortality. The pan-immune-inflammation value is a recently identified biomarker. It reflects the immune and inflammatory status and is rapid, inexpensive, and easy to calculate. In this study, we evaluated the diagnostic power of the pan-immune-inflammation value in patients who developed methanol-induced optic neuropathy.</p> Methods <p>This retrospective, single-center study included 68 patients diagnosed with methanol intoxication between May 2020 and May 2025. Patients were divided into two groups based on the presence or absence of vision loss at admission. Demographic data, laboratory findings, and blood gas values were also analyzed. The pan-immune-inflammation value was calculated using the formula (platelet × neutrophil × monocyte) / lymphocyte. The diagnostic power of PIV in predicting vision loss was evaluated using ROC curve analysis.</p> Results <p>Among the 68 patients included in the study, 32 had vision loss, while 36 did not. In the group with vision loss, neutrophil (<i>p</i> = 0.007), platelet (<i>p</i> &lt; 0.001), and the pan-immune-inflammation value levels (median: 1277.55 vs. 640.05, <i>p</i> &lt; 0.001) were significantly higher, whereas lymphocyte and urea levels were lower. In the ROC analysis, with a cutoff value of 902.15 for the pan-immune-inflammation value, the sensitivity and specificity for predicting vision loss were 90.6% and 91.7%, respectively (AUC: 0.968; 95% CI: 0.934–0.998, <i>p</i> &lt; 0.001).</p> Discussion <p>The findings indicate that pan-immune-inflammation value may serve as a valuable diagnostic biomarker for methanol-induced optic neuropathy, warranting further studies.</p> Conclusion <p>The pan-immune-inflammation value is a parameter that demonstrates high diagnostic accuracy in patients with methanol intoxication. It is inexpensive, rapid, and easy to use. We believe that its use in clinical practice may help facilitate early diagnosis and treatment, thereby contributing to the reduction of permanent blindness and mortality in patients with the pan-immune-inflammation value.</p>

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Diagnostic value of the pan-immune inflammation value in methanol-induced optic neuropathy

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Ertuğrul Altuğ,
  • Adem Çakır,
  • Kemal Şener,
  • Damla Tanış,
  • Ensari Yavuz,
  • Aynur Şahin,
  • Semih Korkut

摘要

Introduction

Methanol intoxication is a significant public health issue that can lead to serious complications such as metabolic acidosis and methanol-induced optic neuropathy. Early diagnosis is critical for reducing permanent vision loss and mortality. The pan-immune-inflammation value is a recently identified biomarker. It reflects the immune and inflammatory status and is rapid, inexpensive, and easy to calculate. In this study, we evaluated the diagnostic power of the pan-immune-inflammation value in patients who developed methanol-induced optic neuropathy.

Methods

This retrospective, single-center study included 68 patients diagnosed with methanol intoxication between May 2020 and May 2025. Patients were divided into two groups based on the presence or absence of vision loss at admission. Demographic data, laboratory findings, and blood gas values were also analyzed. The pan-immune-inflammation value was calculated using the formula (platelet × neutrophil × monocyte) / lymphocyte. The diagnostic power of PIV in predicting vision loss was evaluated using ROC curve analysis.

Results

Among the 68 patients included in the study, 32 had vision loss, while 36 did not. In the group with vision loss, neutrophil (p = 0.007), platelet (p < 0.001), and the pan-immune-inflammation value levels (median: 1277.55 vs. 640.05, p < 0.001) were significantly higher, whereas lymphocyte and urea levels were lower. In the ROC analysis, with a cutoff value of 902.15 for the pan-immune-inflammation value, the sensitivity and specificity for predicting vision loss were 90.6% and 91.7%, respectively (AUC: 0.968; 95% CI: 0.934–0.998, p < 0.001).

Discussion

The findings indicate that pan-immune-inflammation value may serve as a valuable diagnostic biomarker for methanol-induced optic neuropathy, warranting further studies.

Conclusion

The pan-immune-inflammation value is a parameter that demonstrates high diagnostic accuracy in patients with methanol intoxication. It is inexpensive, rapid, and easy to use. We believe that its use in clinical practice may help facilitate early diagnosis and treatment, thereby contributing to the reduction of permanent blindness and mortality in patients with the pan-immune-inflammation value.