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Background <p>While eGFR indicates renal function and NT-pro-BNP aids cardiovascular risk assessment, the prognostic value of their ratio (NT-pro-BNP/eGFR) in non-ST elevation myocardial infarction (NSTEMI) appears to be modest.</p> Aims <p>This study aimed to investigate the relationship between the NT-pro-BNP/eGFR ratio and the severity of angiographically confirmed CAD in NSTEMI patients.</p> Methods <p>This retrospective analysis encompassed 802 patients diagnosed with NSTEMI who received coronary angiography. NT-pro-BNP levels were measured within the first 6&#xa0;h of admission to minimize variability resulting from post-ischemic elevation. The severity of CAD was assessed using the SYNTAX score. ROC curve analysis was used to assess the predictive utility of the NT-pro-BNP/eGFR ratio.</p> Results <p>Patients with SYNTAX scores ≥ 23 (<i>n</i> = 248) had significantly higher NT-pro-BNP/eGFR ratios than those with &lt; 23 (<i>n</i> = 554) (34.56 [16.4–68.1] vs. 19.50 [9.2–33.3]; <i>p</i> &lt; 0.001). A cut-off ≥ 25.54 predicted high SYNTAX scores with 60% sensitivity and 58% specificity (AUC = 0.621; 95% CI: 0.587–0.655; <i>p</i> &lt; 0.001). The ratio remained an independent predictor of CAD severity (OR = 1.440; 95% CI: 1.034–2.007; <i>p</i> = 0.031).</p> Conclusion <p>In NSTEMI patients, the NT-pro-BNP/eGFR ratio is independently associated with the severity of angiographically confirmed CAD. Despite its moderate discriminative power, this low-cost and accessible biomarker may support early risk stratification and identify patients with high atherosclerotic burden who could benefit from more intensive management.</p>

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The association between the NT-pro-BNP/eGFR ratio and coronary artery disease severity in Non-ST elevation myocardial infarction

  • 期刊论文

  • 发表日期：

    2026年4月11日

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  • Nazlı Turan Şerifler,
  • Funda Başyiğit,
  • Hamza Sunman,
  • Ayşe Nur Özkaya İbiş,
  • Belma Yaman

摘要

Background

While eGFR indicates renal function and NT-pro-BNP aids cardiovascular risk assessment, the prognostic value of their ratio (NT-pro-BNP/eGFR) in non-ST elevation myocardial infarction (NSTEMI) appears to be modest.

Aims

This study aimed to investigate the relationship between the NT-pro-BNP/eGFR ratio and the severity of angiographically confirmed CAD in NSTEMI patients.

Methods

This retrospective analysis encompassed 802 patients diagnosed with NSTEMI who received coronary angiography. NT-pro-BNP levels were measured within the first 6 h of admission to minimize variability resulting from post-ischemic elevation. The severity of CAD was assessed using the SYNTAX score. ROC curve analysis was used to assess the predictive utility of the NT-pro-BNP/eGFR ratio.

Results

Patients with SYNTAX scores ≥ 23 (n = 248) had significantly higher NT-pro-BNP/eGFR ratios than those with < 23 (n = 554) (34.56 [16.4–68.1] vs. 19.50 [9.2–33.3]; p < 0.001). A cut-off ≥ 25.54 predicted high SYNTAX scores with 60% sensitivity and 58% specificity (AUC = 0.621; 95% CI: 0.587–0.655; p < 0.001). The ratio remained an independent predictor of CAD severity (OR = 1.440; 95% CI: 1.034–2.007; p = 0.031).

Conclusion

In NSTEMI patients, the NT-pro-BNP/eGFR ratio is independently associated with the severity of angiographically confirmed CAD. Despite its moderate discriminative power, this low-cost and accessible biomarker may support early risk stratification and identify patients with high atherosclerotic burden who could benefit from more intensive management.