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Background <p>ST-elevation myocardial infarction (STEMI) is a critical form of acute coronary syndrome associated with high morbidity and mortality. Inflammation and stress-induced hyperglycemia play significant roles in its pathophysiology. This study aimed to evaluate the prognostic value of inflammatory and glycemic markers for in-hospital mortality in STEMI patients.</p> Methods <p>A total of 119 patients diagnosed with STEMI were included in the study. Demographic characteristics, laboratory parameters, inflammatory and glycemic indices of the patients were recorded. The relationship between in-hospital mortality and the variables was assessed using univariate and multivariate logistic regression analyses. The prognostic performances of the indices were evaluated using Receiver Operating Characteristic (ROC) curve analysis.</p> Results <p>A total of 119 patients (mean age 63.1 ± 1.2 years; 77.3% male) were included. In-hospital mortality occurred in 11.8% of patients. Deceased patients had significantly higher leukocyte and neutrophil counts, neutrophil-to-lymphocyte ratio, glucose, leukoglycemic index (LGI), neutrophil glycemic index (NGI), neutrophil lymphocyte glycemic index (NLGI), urea, and creatinine levels, and lower hemoglobin levels. Multivariate logistic regression identified glucose, LGI, NGI, and NLGI as independent predictors of in-hospital mortality. NGI showed the highest area under the ROC curve (AUC: 0.790, 95% CI: 0.664–0.917).</p> Conclusion <p>Glycemic indices are independent predictors of in-hospital mortality in patients with STEMI. NGI reflects both the inflammatory response, represented by neutrophils, and glycemic stress, thus showing higher prognostic performance than other indices in the acute phase of STEMI. These findings suggest that NGI may serve as a practical and effective biomarker for risk stratification in STEMI.</p>

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Assessment of inflammatory and glycemic markers for in-hospital mortality in STEMI patients

  • 期刊论文

  • 发表日期：

    2026年1月14日

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  • Ali Aygun,
  • Mehmet Seyfettin Saribas,
  • Mesut Tomakin,
  • Adem Koksal,
  • Fatih Akkaya,
  • Ibrahim Caltekin,
  • Mustafa Toprak

摘要

Background

ST-elevation myocardial infarction (STEMI) is a critical form of acute coronary syndrome associated with high morbidity and mortality. Inflammation and stress-induced hyperglycemia play significant roles in its pathophysiology. This study aimed to evaluate the prognostic value of inflammatory and glycemic markers for in-hospital mortality in STEMI patients.

Methods

A total of 119 patients diagnosed with STEMI were included in the study. Demographic characteristics, laboratory parameters, inflammatory and glycemic indices of the patients were recorded. The relationship between in-hospital mortality and the variables was assessed using univariate and multivariate logistic regression analyses. The prognostic performances of the indices were evaluated using Receiver Operating Characteristic (ROC) curve analysis.

Results

A total of 119 patients (mean age 63.1 ± 1.2 years; 77.3% male) were included. In-hospital mortality occurred in 11.8% of patients. Deceased patients had significantly higher leukocyte and neutrophil counts, neutrophil-to-lymphocyte ratio, glucose, leukoglycemic index (LGI), neutrophil glycemic index (NGI), neutrophil lymphocyte glycemic index (NLGI), urea, and creatinine levels, and lower hemoglobin levels. Multivariate logistic regression identified glucose, LGI, NGI, and NLGI as independent predictors of in-hospital mortality. NGI showed the highest area under the ROC curve (AUC: 0.790, 95% CI: 0.664–0.917).

Conclusion

Glycemic indices are independent predictors of in-hospital mortality in patients with STEMI. NGI reflects both the inflammatory response, represented by neutrophils, and glycemic stress, thus showing higher prognostic performance than other indices in the acute phase of STEMI. These findings suggest that NGI may serve as a practical and effective biomarker for risk stratification in STEMI.