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Introduction <p>One of the foremost problems in geriatric patients is the inappropriate medication use (IMU), and several national and international guidelines have been established to define inappropriate medications, including the Turkish Inappropriate Medication Use in the Elderly (TIME) Criteria. We aimed to evaluate the prevalence of IMU among older adults admitted to the emergency room (ER) and to examine its association with clinical outcomes.</p> Materials and methods <p>Patients aged 60 years and older admitted to the internal medicine and geriatric medicine outpatient clinics between January and December 2024 were retrospectively screened, and their emergency room admissions were recorded. The IMU was defined according to the TIME-to-STOP criteria.</p> Results <p>This study included 174 older patients, with a mean age of 76.8 ± 7.7 years and a female representation of 50%. IMU rate was 61.5%. The intensive care unit (ICU) indication was significantly higher in patients with IMU than in those without IMU, with 43.9% of patients with IMU being transferred to the ICU, compared to 28.4% in patients without IMU (<i>p</i> = 0.039). IMU was an independent risk factor for ICU admission among geriatric outpatients, regardless of age, sex, multimorbidity, or polypharmacy (OR: 2.463, 95% CI: 1.027–5.027, <i>p</i> = 0.013).</p> Conclusion <p>IMU was prevalent among older adults admitted to ER, and it was identified as an independent risk factor for ICU admission. These findings underscore the importance of optimizing medication use in geriatric populations to enhance clinical outcomes.</p>

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Inappropriate medication use according to TIME criteria in geriatric outpatients is associated with subsequent intensive care unit hospitalization: A retrospective observational study

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Eda Ural Karaman,
  • Merve Güner

摘要

Introduction

One of the foremost problems in geriatric patients is the inappropriate medication use (IMU), and several national and international guidelines have been established to define inappropriate medications, including the Turkish Inappropriate Medication Use in the Elderly (TIME) Criteria. We aimed to evaluate the prevalence of IMU among older adults admitted to the emergency room (ER) and to examine its association with clinical outcomes.

Materials and methods

Patients aged 60 years and older admitted to the internal medicine and geriatric medicine outpatient clinics between January and December 2024 were retrospectively screened, and their emergency room admissions were recorded. The IMU was defined according to the TIME-to-STOP criteria.

Results

This study included 174 older patients, with a mean age of 76.8 ± 7.7 years and a female representation of 50%. IMU rate was 61.5%. The intensive care unit (ICU) indication was significantly higher in patients with IMU than in those without IMU, with 43.9% of patients with IMU being transferred to the ICU, compared to 28.4% in patients without IMU (p = 0.039). IMU was an independent risk factor for ICU admission among geriatric outpatients, regardless of age, sex, multimorbidity, or polypharmacy (OR: 2.463, 95% CI: 1.027–5.027, p = 0.013).

Conclusion

IMU was prevalent among older adults admitted to ER, and it was identified as an independent risk factor for ICU admission. These findings underscore the importance of optimizing medication use in geriatric populations to enhance clinical outcomes.