Aim <p>This study aimed to determine the effect of psychotherapeutic interventions on pain, quality of life and health profile in women diagnosed with endometriosis.</p> Methods <p>For this systematic review and meta-analysis study, studies were obtained by searching PubMed, Web of Science, EBSCOhost, Google Scholar, and YÖK Thesis Center databases between August and October 2024 without any year limitation. After the review, 10 studies were included in the study. The data were synthesized by meta-analysis and narrative methods.</p> Results <p>In this systematic review and meta-analysis, psychotherapeutic interventions for the treatment and management of endometriosis were found to be effective on quality of life (SMD = 0.515, 95% CI = 0.035 to 0.995; <i>Z</i> = 2.104, <i>I</i>² = 67.523%, <i>p</i> &lt; 0.05), pain (SMD =  − 0.454, 95% CI =  − 1.600 to − 0.179; <i>Z</i> =  − 1.566, <i>I</i>² = 84.463, <i>p</i> &gt; 0.05), and health profile (SMD = 0.041, 95% CI =  − 0.363 to 0.281; <i>Z</i> =  − 0.250759, <i>I</i>² = 56.876%, <i>p</i> &gt; 0.05). In subgroup analyses, it was determined that the types of psychotherapeutic interventions were not effective, but the number of sessions was effective.</p> Conclusion <p>Psychotherapeutic interventions to reduce symptoms in endometriosis are effective in improving quality of life but not pain and health profile.</p>