Objectives <p>Evaluating photodynamic therapy’s efficacy and suitability for treating periodontal disease is the main goal of this review. What are the best conditions for using photodynamic therapy, and how can it improve conventional periodontal treatments?.</p> Materials and methods <p>A comprehensive literature search has been conducted to identify peer-reviewed research published up until August 2024. This search utilized reputable databases, including PubMed, Scopus, and Google Scholar, ensuring a robust selection of relevant studies. Selected studies were meticulously analyzed to their methodologies, types of photosensitizers employed, light intensity levels applied, as well as the resultant clinical outcomes observed. Additionally, a comparative analysis has been performed between photodynamic therapy and traditional periodontal therapy as documented in numerous clinical studies.</p> Results <p>Results show that photodynamic therapy considerably lowers the number of microorganisms present in periodontal pockets, which in turn reduces inflammation and improves healing responses. According to studies, photodynamic therapy is an efficient way to break up the biofilms that of harmful bacteria that cause periodontal disease produce.</p> Conclusions <p>Photodynamic therapy is an intriguing alternative treatment option for periodontal disease. Because photodynamic therapy reduces biofilm resistance, improves blood flow, and promotes healing through anti-inflammatory effects, it may yield better clinical results when used in conjunction with conventional periodontal therapies. More research is required to create consistent guidelines for light dosage and photosensitizer selection in order to maximize therapeutic outcomes.</p>