<p>In this study, biodegradable and shape memory Zn-Ni-Ti-Sc alloys were fabricated by the mechanical alloying-powder injection molding method for temporary implant applications. Traditional Ni-Ti alloys are not biodegradable and need secondary surgery. Zinc, magnesium, and iron are biodegradable metals. Biodegradation of magnesium proceeds too quickly with H₂ evolution, iron is too slow, and zinc is in between. Shape memory alloys can undergo reversible plastic deformation and can return to their initially defined shape. The shape memory effect can be used in bone fracture applications as a compression bone screw, providing compression to the bone. Shape memory behavior provides stable compression of bone fractures. Powder injection molding is suitable for the production of complex parts. There is grain-coarsening and segregation in alloys produced by casting. Alloys with finer grain sizes and low segregation can be produced by using mechanical alloying and powder injection molding. The polymer binder consists of polyethylene, paraffin, and stearic acid. The feedstock consists of 4% binder and 55% alloy. After injection, the binder is removed and then the specimens are sintered. The mechanical, corrosion, and biodegradation properties were investigated. Also, alloys were studied according to computational materials science. Shape memory behavior was determined by compression tests, and 2% shape recovery was found.</p>