<p>This study utilized an orthogonal experimental design to investigate the compressive strength and splitting tensile strength of 102 specimens. The effects of recycled coarse aggregate substitution rate, water-to-binder ratio, and manufactured sand substitution rate on the mechanical properties of manufactured sand-recycled concrete were analyzed. The results indicate that an appropriate incorporation of manufactured sand can enhance the mechanical performance of recycled concrete. The water-to-binder ratio has the most significant impact on the mechanical properties of manufactured sand-recycled concrete. The optimal mix design comprises a water-to-binder ratio of 0.3, a recycled coarse aggregate substitution rate of 40%, and a manufactured sand substitution rate of 70%. The weakening of the bonding strength in the coarse aggregate promotes the strain at which the uniaxial stress reaches its peak. Both compressive and splitting tensile strengths exhibit a positive correlation with the bonding strength in mortar. Reduced mortar strength lowers the elastic modulus under uniaxial stress. The increase in friction coefficient elevates the strain at failure of uniaxial specimens. The rate of increase slows once the friction coefficient exceeds 0.3. The findings provide a theoretical foundation for the promotion and application of manufactured sand-recycled concrete in engineering practices.</p>