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<p>Magnesium-based biodegradable implants are designed to replace permanent implants, eliminating the demand for implant removal by secondary surgery. The Mg-Y-Zn-Mn alloys are outstanding solutions for biomedical purposes due to their superior mechanical properties and moderate biodegradability. This research examines the effect of Y and Zn content and extrusion temperature on the corrosion performance of three Mg-Y-Zn-Mn alloys having a Y/Zn atomic ratio close to 1.5. The corrosion performance was quantified using immersion and polarization corrosion tests within a Hanks solution, and high corrosion resistance of alloys was observed. One of the Mg-Y-Zn-Mn alloys underwent cytotoxicity testing on MG63 cells, and no cytotoxicity was observed. The analysis of the extract composition revealed that after 6-10× dilution, the level of alloy elements in the extract is either close to or lower than the normal daily level for humans. The Mg-3.4 wt.% Y-1.7 wt.% Zn-0.8 wt.% Mn (Mg-1.0 at.% Y-0.6 at.% Zn-0.4 at.% Mn) alloy, after extrusion at 450°C, exhibits a corrosion rate of 0.17&#xa0;mm/year and is not cytotoxic, making it an optimal material for use in manufacturing orthopedic implants.</p>

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Corrosion Properties and Cytotoxicity of Hot-Extruded Mg-Zn-Y-Mn Biodegradable Alloys

  • 期刊论文

  • 发表日期：

    2025年2月24日

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  • V. E. Bazhenov,
  • A. V. Li,
  • V. A. Bautin,
  • S. V. Plegunova,
  • V. V. Vadekhina,
  • D. V. Ten,
  • A. A. Komissarov,
  • A. V. Koltygin,
  • A. Yu. Drobyshev,
  • K. S. Shin

摘要

Magnesium-based biodegradable implants are designed to replace permanent implants, eliminating the demand for implant removal by secondary surgery. The Mg-Y-Zn-Mn alloys are outstanding solutions for biomedical purposes due to their superior mechanical properties and moderate biodegradability. This research examines the effect of Y and Zn content and extrusion temperature on the corrosion performance of three Mg-Y-Zn-Mn alloys having a Y/Zn atomic ratio close to 1.5. The corrosion performance was quantified using immersion and polarization corrosion tests within a Hanks solution, and high corrosion resistance of alloys was observed. One of the Mg-Y-Zn-Mn alloys underwent cytotoxicity testing on MG63 cells, and no cytotoxicity was observed. The analysis of the extract composition revealed that after 6-10× dilution, the level of alloy elements in the extract is either close to or lower than the normal daily level for humans. The Mg-3.4 wt.% Y-1.7 wt.% Zn-0.8 wt.% Mn (Mg-1.0 at.% Y-0.6 at.% Zn-0.4 at.% Mn) alloy, after extrusion at 450°C, exhibits a corrosion rate of 0.17 mm/year and is not cytotoxic, making it an optimal material for use in manufacturing orthopedic implants.